What side effects can Sertraline have?
Below you will find the most important information about possible known side effects of Sertraline.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
Insomnia, dizziness, drowsiness, headache, nausea, diarrhea, dry mouth, delaying ejaculation, fatigue.
Common side effects:
sore throat, refusal to eat, increased appetite, depression, feeling of loss of personality, nightmares, anxiety, excitement, nervousness, decreased libido, teeth grinding, nervous discomfort, tremors, increased muscle tension, taste changes, attention deficit disorders, impaired vision, < left> Ringing in the ears, palpitations, flushing, yawning, abdominal pain, vomiting, constipation, indigestion, flatulence, rash, increased sweating, muscle aches, sexual dysfunctions, erectile dysfunction, chest pain.
Uncommon side effects:
upper respiratory tract infection, runny nose, delusions, euphoria, apathy, disturbed thinking, convulsions, involuntary muscle movements, disturbed coordination, fidgetiness, memory loss, low sensitivity, speech impairment, dizziness in body posture, migraine headache, earache, tachycardia Hypertension, redness of the skin, bronchial spasms, shortness of breath, nosebleeds, esophagitis, dysphagia, hemorrhoids, increased salivation, tongue disease, belching, water retention around the eyes, hives, bone and joint inflammation, muscle weakness, back pain, muscle twitching, disorders of urination ( nocturnal, too frequent, constant), urinary retention, vaginal bleeding, female sexual disorders, malaise, chills, fever, weakness, thirst, weight changes.
Rare side effects:
diverticulitis, gastrointestinal inflammation, otitis media, cancers, lymphadenopathy, blood cholesterol excess, low blood sugar, conversion disorder (deafness, blindness, paralysis without nervous cause), drug dependence, psychotic disorders, aggression, paranoia, Suicidal thoughts and behavior, sleepwalking, premature ejaculation, coma, choreoathetosis, movement disorders, hypersensitivity, sensory disturbances, cataracts, tearing, flashing, double vision, photophobia, redness, dilation of the pupil, heart attack, morbidly slowed pulse, heart disease, circulatory disorders , Throat-pharyngeal convulsions, panting, slowed breathing, wheezing, speech problems, hiccups, black stools, blood stools, inflammation of the mouth, tongue ulcer, dental disease, tongue inflammation, ulceration in the mouth, altered liver function, skin inflammation ng (also blistered), hair follicle inflammation, altered hair structure, altered skin odor, bone diseases, too little urination, urinary incontinence, delayed urination, excessive bleeding, vaginal inflammation with tissue hardening, inflammation of the glans, vaginal discharge, pathological lasting erections, morbid milk flow, intestinal breakage, reduced drug tolerance, Gait disorders, increased liver enzymes (ASAT, ALAT), altered sperm, injury, blood vessel dilation.
Side effects of unknown frequency
lack of white blood cells, platelet deficiency, altered platelet function, allergic reaction, allergy, excess of the hormone prolactin, hypothyroidism, hormonal imbalance of the water, sodium deficiency in blood, diabetes, blood sugar Surplus, horror dreams, movement disorders (fidgetiness, increased muscle tension, upset, teeth grinding or gait disturbances), fainting, seatedness, brain cramps, altered vision, unequal pupils, altered bleeding tendency, lung disease (interstitial pneumonia), pancreatitis, severe liver disorders (including liver inflammation, jaundice and Liver failure), severe skin reactions (Stevens-Johnson syndrome and epidermal necrolysis), blood vessel swelling, facial swelling, photosensitivity, skin reaction, itching, joint pain, muscle cramps, wetting, breast swelling, menstrual disorders mentions, water retention in the arms and legs, conspicuous laboratory results, elevated blood cholesterol.
After completing treatment with sertraline, agitation, anxiety, dizziness, headache, nausea and nervous discomfort have been reported. These complaints usually resolve within two weeks, but may last for two to three months or more. Termination of treatment sol
What interactions does Sertraline show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Sertraline must not be given with MAO inhibitors, including selegiline, moclobemide and the antibiotic linezolid. There are reports of serious side effects and deaths. At least 14 days should elapse between the end of treatment with sertraline and a MAO inhibitor.
Sertraline increases the blood levels of the neuroleptic pimozide. Due to the danger of poisoning both should not be taken together.
Medical attention should also be given to the use of the opioid analgesic fentanyl during general anesthesia or for the treatment of chronic pain.
The stomach remedy Cimetidine (a H
During treatment with sertraline should be dispensed with the consumption of alcohol.
Concomitant use of sertraline and warfarin (anticoagulant) showed a small prolonged clotting time. Therefore, coagulation should be carefully monitored when initiating or stopping therapy with sertraline. The risk of bleeding may also be increased if antiplatelet agents (such as non-steroidal anti-inflammatory drugs, acetylsalicylic acid and ticlopidine) or other agents that may increase the risk of bleeding are given concomitantly with sertraline.
Increased tremor was a side effect when taking lithium at the same time.
Blood levels of epilepsy drug phenytoin should be controlled after initiating sertraline therapy. Also, phenytoin can reduce the blood levels of sertraline and thus weaken its effects.
Given together with the migraine remedy sumatriptan, weakness, reflex enhancement, movement disorder, confusion, anxiety and excitement have been reported rarely.
Sertraline hinders the breakdown of some substances in the body. This should be noted by the physician, especially at higher sertraline doses. Examples are the psychotropic drug desipramine, but also antiarrhythmics such as propafenone and flecainide, tricyclic antidepressants and other typical psychotropic drugs.
Sertraline itself is inhibited in its breakdown by grapefruit juice, which can lead to a doubling of blood concentration. Therefore, the intake of grapefruit juice during treatment with sertraline should be avoided. Sertraline behaves similarly with other drugs that inhibit the degrading enzymes. These include H1 protease inhibitors, the fungicides fluconazole, ketoconazole, itraconazole, posaconazole and voriconazole, the antibiotics clarithromycin, erythromycin and telithromycin, the antihypertensives verapamil and diltiazem and the psy- chopharmacon nefazodone. A combination should therefore be avoided as far as possible.
Since delays in breakdown associated with the stomach remedies omeprazole, lansoprazole, pantoprazole and rabeprazole and the antidepressants fluoxetine and fluvoxamine can not be ruled out, the physician will carefully monitor such patients.