One capsule contains:
Active substance: Orlistat – 120 mg.
Excipients: microcrystalline cellulose, sodium starch-glycolate, povidone, sodium lauryl sulfate, talc.
Form of release
Capsules 120 mg 21 in a blister pack of 1.2 or 4 blisters.
It is released on prescription.
Indications for use
Long-term therapy for obese patients or patients with overweight, including those associated with obesity risk factors, combined with a moderately hypocaloric diet.
In combination with hypoglycemic drugs (metformin, sulfonylureas and/or insulin preparations) or moderate hypocaloric diet in patients with type 2 diabetes with overweight or obesity.
Mode of application
The recommended dose of orlistat is one 120 mg capsule with each main meal (during meals or no later than one hour after a meal). If food intake is missed or if the food does not contain fat, then Xenical can also be missed.
The patient should receive a balanced, moderately hypocaloric diet containing no more than 30% of calories in the form of fats. The daily intake of fats, carbohydrates, and proteins must be divided into three main methods.
Increasing the dose of orlistat more than the recommended (120 mg 3 times a day) does not lead to an increase in its therapeutic effect.
The effect of orlistat in patients with liver or kidney damage and children has not been studied.
Xenical is effective regarding long-term control of body weight (reduction in body weight and its maintenance at a new level, prevention of repeated weight gain).
Treatment with Xenical leads to an improvement in the profile of risk factors and diseases contributing to obesity, including hypercholesterolemia, type 2 diabetes, impaired glucose tolerance, hyperinsulinemia, arterial hypertension, and a reduction in visceral fat.
When used in combination with such hypoglycemic drugs as metformin, sulfonylurea preparations and/or insulin in patients with type 2 diabetes with excessive body weight, Xenical, combined with a moderately hypocaloric diet, gives an additional improvement in the compensation of carbohydrate metabolism.
In clinical studies, in most patients the concentrations of vitamins A, D, E, K, and beta-carotene remained normal within two or three full years of orlistat therapy. To ensure adequate intake of all nutrients, multivitamins can be prescribed.
The patient should receive a balanced, moderately hypocaloric diet containing no more than 30% of calories in the form of fats. We recommend eating rich in fruits and vegetables. The daily intake of fats, carbohydrates, and proteins must be divided into three main methods.
The likelihood of adverse reactions from the gastrointestinal tract may increase if Xenical is taken amid a diet rich in fats (for example, 2000kcal / day, of which more than 30% is fat, which is about 67g of fat). Daily intake of fat should be divided into three main methods. If Xenical is taken with food, very rich in fat, the likelihood of gastrointestinal reactions increases.
In patients with diabetes mellitus type 2, weight loss during treatment with Xenical is accompanied by an improvement in the compensation of carbohydrate metabolism, which may or may require a reduction in the dose of hypoglycemic drugs.