About Tamoxifen

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About Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

What is the purpose of this ingredient?

  • Prevent recurrence of mammary cancers
  • Inhibit the development of secondary tumors
  • Destroy mammary cancer cells and their secondary tumors

This is how Tamoxifen works

Below you will learn more about the fields of application and the mode of action of tamoxifen.
Please also read the information on the drug classes antiestrogens, cytostatics, to which the active ingredient tamoxifen belongs.

Application of the active ingredient Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

In addition, tamoxifen has been shown to be effective in preventing breast cancer in high-risk patients in a four-year clinical trial (National Surgical Adjuvant Breast and Bowel Project).

For the following application areas of Tamoxifen , in-depth information is available:

  • breast cancer

Effect of Tamoxifen

Some cancers are promoted in their formation and growth by hormones. This is, for example, the case of breast cancer, whose development and spread is dependent on the female sex hormone estrogen. The estrogen attaches to special hormone receptors on the cancer cells and stimulates them to grow.

Tamoxifen belongs to the drug class of antiestrogens and typically blocks the binding of estrogen to the hormone receptor of cancer cells. Due to the lack of growth signal by the hormone there is a decrease in cell proliferation. In the case of metastatic breast cancer, treatment with tamoxifen causes complete or partial regression in about 30% of cases, especially of the secondary tumors in the soft tissues and bones. The probability of recurrence is even around 50 to 60 percent if the presence of estrogen receptors in the tumor tissue has been proven.

In early-stage breast cancer, prolonged non-relapse and survival time can be achieved by tamoxifen therapy after surgery.

Tamoxifen itself does not inhibit the growth of cancer cells. The active substance is converted into the active form endoxifen after absorption into the body in the liver by the enzyme CYP2D6.

Potential Tamoxifen side effects may include:

Tamoxifen used to treat the following diseases:

Disease
Percentage
1%