About Tamoxifen

3.5 rating based on 123 ratings
Rating: 3.6 Reviews: 123
About Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

What is the purpose of this ingredient?

  • Prevent recurrence of mammary cancers
  • Inhibit the development of secondary tumors
  • Destroy mammary cancer cells and their secondary tumors

This is how Tamoxifen works

Below you will learn more about the fields of application and the mode of action of tamoxifen.
Please also read the information on the drug classes antiestrogens, cytostatics, to which the active ingredient tamoxifen belongs.

Application of the active ingredient Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

In addition, tamoxifen has been shown to be effective in preventing breast cancer in high-risk patients in a four-year clinical trial (National Surgical Adjuvant Breast and Bowel Project).

For the following application areas of Tamoxifen , in-depth information is available:

  • breast cancer

Effect of Tamoxifen

Some cancers are promoted in their formation and growth by hormones. This is, for example, the case of breast cancer, whose development and spread is dependent on the female sex hormone estrogen. The estrogen attaches to special hormone receptors on the cancer cells and stimulates them to grow.

Tamoxifen belongs to the drug class of antiestrogens and typically blocks the binding of estrogen to the hormone receptor of cancer cells. Due to the lack of growth signal by the hormone there is a decrease in cell proliferation. In the case of metastatic breast cancer, treatment with tamoxifen causes complete or partial regression in about 30% of cases, especially of the secondary tumors in the soft tissues and bones. The probability of recurrence is even around 50 to 60 percent if the presence of estrogen receptors in the tumor tissue has been proven.

In early-stage breast cancer, prolonged non-relapse and survival time can be achieved by tamoxifen therapy after surgery.

Tamoxifen itself does not inhibit the growth of cancer cells. The active substance is converted into the active form endoxifen after absorption into the body in the liver by the enzyme CYP2D6.

Potential Tamoxifen side effects may include:

Tamoxifen used to treat the following diseases:

Disease
Percentage
1%
  1. Margaret V. Jones says:
    4.0 rating

    Tamoxifen for Breast cancer

    After taking Tamoxifen for 15 months, I am currently ready to discontinue this drug on the spot. The hot flashes are limited, worse is the total exhaustion and fatigue. Can not go 50 steps without being completely out of breath, climbing stairs is an abomination !!! Because of diabetes melitus 2, I have been trying for some time to lose weight. Unfortunately this does not succeed. In addition, there is a buildup of water in the right ankle, occasionally bone and joint pain, which I get control of with Voltaren tablets. Since the second month of use, increased vaginal discharge has occurred. Since I have a lot to do in my job and my quality of life is also very important to me, I will try to have other tablets like Fareston or Evista prescribed.

  2. Isabel D. Robinson says:
    4.5 rating

    Tamoxifen for Breast cancer

    I am taking Tamoxifen 20mg since January 2010. First, I had extreme hot flashes and sweats. This has settled after about 4 – 5 months. Hot flashes rarely occur. But I suffer from severe bone pain and water retention, especially in the feet. I have totally broken fingernails. However, what I am particularly worried about is the weight gain of now about 12 kg. And my eyesight has deteriorated in the past few months. Lymphatic drainage helps with the water retention, I take homeopathic remedies for joint pain. Furthermore, I started Nordic Walking. Since then, my general condition has improved a lot.

  3. Margaret J. Kuhn says:
    4.5 rating

    Tamoxifen for Breast cancer

    After breast-conserved surgery, chemo and radiation, I got zoladex and tamoxifen prescribed for 1 year from July 2008. In the first year I took between 5 and 8 kilos, sporty was almost nothing. Every staircase was a pain, I ran out of steam, housework takes twice as long and jogging (previously 3x weekly 1-1 1/2 hours) was unthinkable. Since taking I am struggling with sleep disorders (max. 3 hours sleep per night), fatigue and hot flashes. After finishing with Zoladex it was at least physically up again a bit. My athletic motivation is on the rise. Weight problems (especially stomach), deterioration of visual acuity, hair loss and brittle fingernails. Have a health practitioner visited and so at least the tiredness and hot flashes have improved. I’m really thinking of whether I still go through the remaining 2 years of tamoxifen intake!

  4. Donna M. Gordon says:
    4.5 rating

    Tamoxifen for Breast cancer

    Tamoxifen for a year. Full program breast cancer surgery at the age of 48 years, breast conservative, chemo (6 times a session) and 36 times radiation. And now the side effects, insane hot flashes, sleepless nights, depression, lack of concentration, toenails had loosened, since March frail thin-grooved thin, badly growing fingernails, torn fingertips, so that sometimes you can barely handle. Vaginal discharge or abdominal pain and bone pain comlettis. Problems with the sense of taste. So, everything that the others have.

  5. Phyllis J. Gray says:
    5.0 rating

    Tamoxifen for Breast cancer

    Slowly and very insidiously, the side effects have set and strengthened so much that I discontinued the drug prematurely after taking one year. By the side effects (especially strong pain in all joints and muscles, listlessness, hair loss, nail brittleness, strong mood swings, sleep problem etc.) my quality of life was so severely limited that it became unbearable! The drug has actually done its work, but – from my personal point of view – the price is too high.

  6. Madeline R. Hamilton says:
    4.5 rating

    Tamoxifen for Breast cancer

    After the third breast surgery and removal of the right breast, I was prescribed FEMARA. I take this medicine now half a year. After a short time of taking already significant increase in body weight. Listlessness, depression, memory failure, skin rash pimples. Listlessness in the sex life. The quality of life has diminished considerably. Now, after talking to my gynecologist and contacting an oncologist, try to get another solution or medicine. In the last five years of my breast cancer, I took tamoxifen and had virtually no side effects. 28/05/2011

  7. Helen R. Carter says:
    3.5 rating

    Who can give me a hint? In 2011 I had undergone breast conserving surgery on a lime deposit in the chest. So far so good, since 3 years I take Tamoxifen, altogether it is to be taken 5 years, says my gynecologist. Before that, I had 28 radiations, for about 10 months I had such heavy legs and body aches, as if I were shocked many miles every day. Even small efforts or long walks bring great pain in the legs and back and the night is already over. I have never had such a problem, no problems, who is the same, maybe there is another drug, which is more compatible and does not have these side effects? Doro

    Side effects: Members hurt
  8. Virginia R. Carroll says:
    2.5 rating

    Tamoxifen for Breast cancer

    take tamoxifen is 8 mon. in addition zometa and trenantone. heat flashes up to 30 on the day of concentration disturbances chills and cold sensation even in high summer, but still after 5 hrs. work is 2 hours. lie down hip (recharge) HAVE LESS WITH LEGS. but that medicine keeps me alive. So you have to look at the whole thing a bit sporty.

  9. Melody C. Francois says:
    2.5 rating

    Tamoxifen for Breast cancer

    have just described my experience, comes to this: bone pain, muscle weakness, especially after Zometa (1/4 a year) for 2 nights chills and body aches, after taking ibuprofen better. Also gaining weight overall by taking tamoxifen and Herceptin (treatment ended on 13/03/2008)

    Side effects: Members hurt; Chills; Bone pain
  10. Willie W. Fisher says:
    3.0 rating

    Tamoxifen for Breast cancer

    I think I have everything there is to side effects. Hizblasungen but the finest. I have gained about 25 kg, water accumulation spread over the whole body, extreme in the hands and legs. Shortness of breath is also nothing extraordinary not only under stress. Some of my joints hurt all day. At 49, I feel like an old woman. Even my eyes have changed / worsened and burn constantly. Sleep in one piece, again a whole night, would be great, but not more. Add to that fatigue and fatigue. The meantime extreme hair loss has improved a bit, but the hair is brittle and dull. Fragile are my fingernails. So I think I could go on. If I was not that stubborn, I’d have dropped that stuff long ago.

  11. Dorothy D. Sterling says:
    4.0 rating

    Tamoxifen for Breast cancer

    I’ve been taking Tamoxifen 20 for almost 1 year, plus I’ve been following Herceptin treatment for 1 year …. I’ve had a lot of bone and back pain and itching all over my body, and of course a few pounds. I’m still alive and I’m glad that there are any medicines for prevention …

  12. Vicenta J. Williams says:
    3.5 rating

    Tamoxifen for Breast cancer

    About 2 weeks after the start of treatment, the first side effects occurred. Nocturnal leg cramps, hot flashes, sleep disturbances. Take the drug now for 4 weeks and it has remained with these side effects so far. I hope now that there will be no other adverse effects from the drug during treatment.

  13. Mary M. Smith says:
    4.0 rating

    Tamoxifen for Breast cancer

    My experiences are, I have very strong Schweisausbrüche, Gefühsschwankungen, joint pain but only when it is cold. I have already gained 7 kg in weight, that bothers me a lot. From time to time I am Depressed and Aggressive. I can live well with that, but not with the increase in weight, that still makes me crazy. I often have sleep problems as well. I would prefer to take nothing more. With the removal of the ovaries, I thought I need tamoxifen no longer take, but unfortunately it was not so. I’m totally draughty about my weight, and my gynecologist’s statement is just that, that’s normal.