About Tamoxifen

3.5 rating based on 123 ratings
Rating: 3.6 Reviews: 123
About Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

What is the purpose of this ingredient?

  • Prevent recurrence of mammary cancers
  • Inhibit the development of secondary tumors
  • Destroy mammary cancer cells and their secondary tumors

This is how Tamoxifen works

Below you will learn more about the fields of application and the mode of action of tamoxifen.
Please also read the information on the drug classes antiestrogens, cytostatics, to which the active ingredient tamoxifen belongs.

Application of the active ingredient Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

In addition, tamoxifen has been shown to be effective in preventing breast cancer in high-risk patients in a four-year clinical trial (National Surgical Adjuvant Breast and Bowel Project).

For the following application areas of Tamoxifen , in-depth information is available:

  • breast cancer

Effect of Tamoxifen

Some cancers are promoted in their formation and growth by hormones. This is, for example, the case of breast cancer, whose development and spread is dependent on the female sex hormone estrogen. The estrogen attaches to special hormone receptors on the cancer cells and stimulates them to grow.

Tamoxifen belongs to the drug class of antiestrogens and typically blocks the binding of estrogen to the hormone receptor of cancer cells. Due to the lack of growth signal by the hormone there is a decrease in cell proliferation. In the case of metastatic breast cancer, treatment with tamoxifen causes complete or partial regression in about 30% of cases, especially of the secondary tumors in the soft tissues and bones. The probability of recurrence is even around 50 to 60 percent if the presence of estrogen receptors in the tumor tissue has been proven.

In early-stage breast cancer, prolonged non-relapse and survival time can be achieved by tamoxifen therapy after surgery.

Tamoxifen itself does not inhibit the growth of cancer cells. The active substance is converted into the active form endoxifen after absorption into the body in the liver by the enzyme CYP2D6.

Potential Tamoxifen side effects may include:

Tamoxifen used to treat the following diseases:

Disease
Percentage
1%
  1. Brian C. Pasko says:
    4.0 rating

    Tamoxifen for Breast cancer

    Hello, I had breast cancer 3 years ago in the initial stage in the left breast. Luckily, I did not need chemo or radiation, but I was operated on. My left breast was completely cleared and rebuilt with an implant which also took a bit of muscle out of my back. Since 3 years I take the drug Tamoxifen where I have to fight with some real. I have gained weight through healthy Apettit 🙂 the stuff is really hungry …. Hot flash, I’m a lot tired and sometimes really pretty irritated. My rule is very irregular. But I comfort myself with the fact that I have to endure it only 2 years and my best friend is always there for me …. no matter how I look …. no matter how I am on it. I hope I could give you all a little courage. My favorite quote: DO NOT DREAM YOUR LIFE LIFE YOUR DREAM!

    Side effects: Irritability; Fatigue; Hot flashes
  2. Joan J. Bowers says:
    3.0 rating

    Tamoxifen for Breast cancer

    I have been taking Tamoxifen since July 2010. I have hot flashes mainly at night and joint pain in my legs, which are bearable. Before the start of therapy I had strong and frequent hot flashes, also during the day, which has improved since taking tamoxifen. Weight loss up to now about 5 kg. I have the feeling that my general condition has improved since starting tamoxifen therapy. However, I realized now that my fingernails splinter and my hair is not so good to style. I hope that will happen again in the course of the therapy. Otherwise, I hope the drug works.

  3. Steven T. Odell says:
    4.0 rating

    I am taking tamoxifen for 2 years now after a hormonal breast cancer surgery. I can not report anything negative except that my eyes have deteriorated. But that is bearable with appropriate glasses. As I do a lot of sports (3 x per week gym, 2 x dancing) I feel like I’m in top shape. I have neither bone problems nor do I feel cut off. However, I pay close attention to my weight. I weigh myself in the morning and in the evening. I am 51 years, 170 tall and weigh 65 kilos. I lost 5 kg with tamoxifen. I have to take Tamoxifen for another 3 years and hope that I will feel so good afterwards.

    Side effects: Weight loss; Vision loss
  4. Laura B. Midkiff says:
    3.0 rating

    Tamoxifen for Breast cancer

    I can only experience to the contrary that I lost 8kg in 18months without change of diet, did not have any more mastopathies which were very painful and after 15 months the period did not materialize, which I found very positive. Disadvantage is the joint and bone pain (where I possibly tamoxifen absetze) because I work in amb. Nursing work, where much physical use is verlant. Hitzwallung I did not feel annoying.

  5. Chrystal J. Cage says:
    2.0 rating

    Tamoxifen for Breast cancer

    after chemo + irradiation since 2004 tamoxifen.No weight gain but skin dryness on the body, hair growing like weeds. (were never so beautiful.) However, cough since taking, fatigue, skin aging, bone pain especially in the hands and shoulders, bladder weakness (doctor says: through the hormone withdrawal). Otherwise, no further incidents, so the medi can recommend. I’m done with it soon and would do it again. All follow-up examinations were great, wish all concerned the same ……

  6. Sandra B. Wood says:
    4.0 rating

    Tamoxifen for Breast cancer

    Nausea in the first few months, dry skin, brittle fingernails, muscle u. Joint pain in arms, hands u. Feet. No weight gain, no vaginal dryness, no libido loss. Take the drug with conviction and do not suffer from depression. However, after about 1 year cough has become noticeable, which has remained until today. After 5 years I will discontinue the drug because it is exhausted in terms of performance.

    Side effects: To cough; Skin dryness; Nausea
  7. Lindsey D. Morton says:
    4.0 rating

    Tamoxifen for Breast cancer

    I had just a double Lundegnembolie, am & lt; Friday from the hospital back with a giant oxygen bottle plus small to go out !!! I refuse to continue tamoxifen nor any other remedy. I’ve got that. I had a short breath that I could not walk 4 paces anymore. stinging pain in the back when coughing …

  8. Doyle D. Mendoza says:
    2.5 rating

    Tamoxifen for Ormond

    Am male and must take this medicine because of the rare Ormond disease. Side effects Cramps Fatigue Fatigue Constant freezing Problems with the leg nerves, heavy hair growth slower building a male breast, fatigue

    Side effects: Cramps; Cold feeling; Fatigue
  9. Stephanie M. Coleman says:
    4.0 rating

    Tamoxifen for Overweight

    After my breast cancer in 2007, I received radiation and took tamoxifen, did not need chemo, but either zoladex or ovarian removal, opted for ovarian removal. Tamoxifen was well received at the time, and for the first two years, the tamoxifen had to go to sleep in the evening, because the side effects were extreme, night sweats, rashes, palpitations, extreme nausea, water retention, and an enormous weight gain. Now after three years I had to sell the tamoxifen, I’m sitting so full of water that I can not get rid of it. Was today at the gynecologist, because the water presses on my joints and it hurts, have reported that the oncologist advised me against the adoption of tamoxifen. Yes, now I have to take blood and searching begins. Weight gain about 30 kg

  10. Tina J. Evans says:
    2.5 rating

    After a long period of ingestion, leg edema, which is solely due to tamoxifen, now forms.

    Side effects: Edema
  11. Frances S. Slavin says:
    4.0 rating

    Tamoxifen for Breast cancer

    After chemotherapy and radiation I started tamoxifen. Since then, my eyes have become much worse. In addition, I suffer from edema, weight gain, numb feet and fingers, hair loss, vaginal dryness and bone pain. I hope that over time it will be possible to work normally again. At the moment, I struggle to do anything for a few hours a day.

  12. Sandra A. Walden says:
    3.0 rating

    Tamoxifen for Breast cancer

    Hot flashes of tamoxifen in the beginning were very strong, but then significantly less. Bones u. Joint pain was bearable, I could with gymnastics, Nordic walking, swimming thermal bath, warm showers, a lot of exercise, well he wear. After taking Femara, the complaints were much stronger, in addition to thinner hair, inflammation of the mouth have increased, dry eyes. Hot flashes have gotten better, but now I’m tired faster after physical work. My bones-u. Joint pain is especially severe during rest and nocturnal awakenings. At the joint approaches I have pressure pain, can not wring out very well wipes, can not clean well, had a lumbar spine surgery after herniated disc 4 years ago. Will that get better after stopping taking Femara? What else can I do to make it more bearable except taking Diclofenac 75, which will help me well but not so often? I have to last another two years.

  13. Charles P. Linn says:
    4.0 rating

    Tamoxifen for Breast cancer

    I had breast cancer in 2009, which was due to hormones. When I have to take tamoxifen after the irradiation, I am soon tricked out. Had just wanted to beat me, was from minute to the other minute something of strange, I had not recognized me again .First cheered and I wanted to tear out trees, in the näxten minute I would have jumped out of the window. My Physiotherapheut says I’m manic, that’s me too. Then the doc said I have to take the monthly injection, the would be the hammer.Enatone-gyn.und seut the torment me every day, lack of motivation, hot flashes, I get nothing more in the series and that is how agonizing die.jeden day.ich I got help, because I was completely alone ‘I’ve gained 30 kilos and it’s getting more and more, even if I eat nothing. It’s cruel. And I do not want to live like that anymore. Today I sat down and swore I would not take it that way.

  14. Cynthia D. Webber says:
    3.0 rating

    Tamoxifen for Breast cancer

    Tamoxifen: cramps, nocturnal urination, vaginal discharge Femara: morning stiffness Feet and fingers, recurrent inflammation in the elbow, crunching in the knee joints, appetite increase with weight gain, connective tissue changes, depressive or irritable moods, hair loss, concentration problems