Symbicort side effects

What Side Effects Budesonide Can Have?

Below you will find the most important information about possible known side effects of budesonide.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Side effects of inhalation:
Hoarseness, coughing, irritation of the oropharynx, fungal infection of the mouth and throat.

bronchospasm, skin rash, hives, itching, redness, facial swelling, contact dermatitis, adrenal hyperthyroidism, adrenal function, growth retardation, hypersensitivity reactions, allergic shock, depressive moods, aggressiveness, irritability, anxiety, psychosis, behavioral disorders ( especially in children), restlessness, nervousness.

Very rare and occasionally occurring:
Eye diseases such as cataracts, cataracts, suppression of adrenal function, reduction of bone density.

Adverse reactions when applied to the nose:
local irritation of the mucosa, bloody secretions, nosebleeds (immediately after application).

immediate or delayed hypersensitivity reactions (including hives, rash, itching, dermatitis, facial swelling).

Signs of holistic glucocorticoid effect (acne, adrenal hypofunction).
For long-term use: osteoporosis, increased intraocular pressure (glaucoma), lens opacification (cataract).

Very rare and occasionally occurring:
holes in the nasal septum, ulcers of the nasal mucosa, speech disorders.

Side effects when used in the rectum:
flatulence; Nausea; Diarrhea, hives, rash.

restlessness, insomnia.

Very rare and occasionally occurring:
Allergic reaction.

Side effects of unknown frequency:
Green Star.

Side effects when taking:
Nausea, upper abdominal pain, headache, insomnia, mood changes, decrease in cortisol concentration in the blood, flu, upper respiratory virus infection.

bloated abdomen, abdominal pain, diarrhea, indigestion, drowsiness, acne, lack of drug action, pain in arms and legs, Cushing’s syndrome, anemia.

itching, fatigue (fatigue), water retention in arms and legs.

Special features:
When switching from a treatment of budesonide in tablet form to an inhalation treatment, allergic reactions may occur which have been suppressed by the previous treatment. In this case, the dosage must be readjusted by the doctor.

Budesonide inhalation may cause infections with bacteria and fungi, especially around the mouth and throat area (fungal infections in the mouth). These must be treated after consultation with the doctor accordingly.

All topical applications of budesonide may also have effects on the whole body if the patient is particularly sensitive and / or prolonged use. It can then cause side effects that are known from taking the drug.

What interactions does budesonide show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

The active ingredient budesonide potentiates the effects of the beta-2-sympathomimetics used in asthma, such as salbutamol, fenoterol, salmeterol or formoterol. These active ingredients also dilate the bronchi and thus support the effect of budesonide.

Active ingredients such as the antifungal agents itraconazole, ketoconazole, the anti-AIDS drugs ritonavir and nelfinavir, the troleandromycin and erythromycin antibiotics and ciclosporin against organ transplantation, but also grapefruit juice inhibit the breakdown of budesonide in the body and may therefore exacerbate effects and also cause the side effects of budesonide.

Drugs such as the antiepileptic carbamazepine and the antibiotic rifampicin promote the breakdown of budesonide and may thus reduce the general as well as the local effect of budesonide on the intestinal mucosa. An adjustment of the Budesonid dosage by the physician may be necessary.

Budesonide is broken down by the same enzyme as the hormone ethinylestradiol. In women who have received concomitant oral sex hormones (estrogens) or estrogen-progestagen contraceptive (“pill”) combinations, increased blood levels of budesonide and increased potency have been reported. This interaction did not occur with concomitant use with low dose combinations for contraception (“minipill”).

Since all corticosteroids – including budesonide – promote the excretion of potassium, the following interactions should be noted: A possible potassium deficiency promotes the effect (and side effects) of cardiac glycosides and the potassium excretion caused by certain dehydrating agents may be enhanced.

Potential Symbicort side effects may include: