Following is information on contraindications to the use of sunitinib in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Sunitinib not be used?
In case of hypersensitivity to the active ingredient sunitinib should not be used.
Only after careful consideration of the benefit and risk by the physician and under his control may the active substance be used in
- Patients at risk for cardiac dysfunction and / or coronary heart disease because heart failure may develop
- pre-existing severe heart disease, slow heartbeat, or mineral disorder, because cardiac arrhythmias may occur in the sense of QT prolongation
Cases of massive cancerous tumors, pre-existing chronic renal impairment, dehydration, lack of water excretion, acid urine, or low blood pressure because they are risk factors for a so-called tumor lysis syndrome with collapse of kidney activity.
What should you watch out for during pregnancy and lactation?
There are no studies on the use of sunitinib in pregnant women. In animal experiments, however, malformations were found in the unborn child. Therefore, the active substance should not be used during pregnancy or in women without adequate contraception. Unless the doctor considers the potential benefit more important than any risk to the child.
Sunitinib and / or its breakdown products are released into the milk in rats. It is not known if this is also the case in humans. Since active ingredients are often released into breast milk and since sutinib causes severe side effects in breast-fed infants, women should not breast-feed as long as they are taking the medicine.
There is a possibility that male and female fertility may be compromised by treatment with sunitinib.
What should be considered in children?
The safety and efficacy of sunitinib in patients less than 18 years old has not been established.
Warnings and Precautions
- When treatment with the drug can be resumed after surgery, the doctor will decide on the progress of wound healing.
- For patients treated with the drug, the doctor will create a blood count at the beginning of each treatment cycle.
- Diabetes patients should have their blood sugar levels checked regularly.
- Before the treatment with the drug, a dentist should be consulted to assess the condition of the jawbone.
- If symptoms of heart failure, clogging of the smallest blood vessels, pancreatitis, liver failure, facial swelling, myalgia or kidney damage occur, treatment with the drug should be discontinued.
- Therapy with the drug should only be started and monitored by an experienced cancer doctor.
- If dizziness occurs during treatment with the drug, driving and operating machinery is dangerous.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.