What side effects can sunitinib have?
Below you will find the most important information about possible known side effects of sunitinib.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
anemia, lack of blood cells (platelets, neutrophils, white blood cells), hypothyroidism, decreased appetite, insomnia, dizziness, headache, taste disorder, low blood pressure, difficulty breathing, nosebleeds, cough, mouthbleeds, abdominal pain, nausea and vomiting , Diarrhea, constipation, indigestion, skin discoloration, discomfort of the palms,
Common side effects:
viral infections, respiratory infections, abscess, fungal infections, urinary tract infections, skin infections, blood poisoning, lack of lymphoid cells, dehydration, low blood sugar, depression, nervous disorders, nervous disorders, sensory disorders, swelling around the eye socket, eyelid swelling, increased tears, circulatory disturbances of the heart muscle, decreased cardiac output, obstruction of low-lying veins, hot flash, heat sensation, pulmonary embolism, pleural effusion, spitting blood, dyspnoea under pressure, nasopharyngeal pain, nasal obstruction, dry nasal mucosa, acid reflux from the stomach, < swallowing disorder, gastrointestinal bleeding, esophagitis, distended stomach, abdominal discomfort, bleeding from the bleeding, bleeding gums, mouth ulcers, rectal pain, lip irritation, hemorrhoids, burning tongue, mouth pain, dry mouth, flatulence, mouth discomfort, belching, skin peeling, skin reaction, eczema, skin blister , skin redness, alopecia, acne, itching, yellowing of the skin, skin damage, calluses, dermatitis, nail disease, muscle and skeletal system pain, muscle spasms, muscle weakness, kidney failure (also acute), yellowing of the urine, protein in the urine, chest pain basket, general pain, flu-like illness, chills, decreased body weight, decreased blood components (white blood cells, platelets, red blood pigment), increased blood levels (lipase, amylase, asat, alat, creatinine, uric acid) Side effects :
Decomposition of muscle surrounding skins (fascia), infection with bacteria, deficiency of all blood cells, hypersensitivity, hyperthyroidism, cerebral hemorrhage, stroke, transient circulatory disorder of the brain, (poorly treatable) heart failure, myocardial infarction, heart muscle disease, pericardial effusion, QT prolongation in ECG, tumor bleeding, pulmonary haemorrhage, respiratory dysfunction, gastrointestinal breakthrough, pancreatitis, fistula at the anus, liver failure, gall bladder inflammation, abnormal liver function, jawbone, bone fistula, urinary tract bleeding, delayed wound healing, increased creatine kinase in the blood, increased thyrotropin i Morbid side effects:
Constipation of small blood vessels, facial swelling, thyroid inflammation, tumor lysis syndrome, temporary brain disease (posterior reversible encephalopathy syndrome), left ventricular dysfunction, cardiac arrhythmia (Torsade de pointes), Liver inflammation, severe skin reactions (erythema multiforme, Stevens-Johnson syndrome, pyoderma gangrenosum, toxic epidermal necrolysis), muscle tissue breakdown, muscle disease, nephrotic syndrome
In patients receiving sunitinib At the beginning of each treatment cycle, the doctor will create a blood count.
Treatment with sunitinib must be stopped at
- signs of heart failure
- Constipation of the smallest blood vessels and anemia, fatigue, nervous disorders, impaired kidney function and fever
- signs of pancreatitis with, for example, upper abdominal pain
- Signs of liver failure (nausea and vomiting, yellowing of the eyeballs)
- Hypersensitivity, which manifests itself in facial swelling
- Muscle pain because they may indicate a disintegration of muscle surrounding skins
- Signs of nephrotic syndrome (flocculation in urine, fluid retention in tissue).
During treatment with sunitinib, regular medical control of thyroid function is required every three months.
Sunitinib hinders wound healing. The doctor will therefore make the decision dependent on their progress,
What interactions does sunitinib show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Caution is advised when administering sunitinib and bisphosphonates as an infusion for osteoporosis either simultaneously or consecutively. A strong degradation of the jaw bones can be the result.
Sunitinib is degraded by an easily influenced enzyme system. Highly effective inhibitors of this system can lead to more side effects. These include the antiviral agent ritonavir, the fungicides ketoconazole and itraconazole, the antibiotics erythromycin and clarithromycin. But grapefruit juice is one of these substances and should therefore be avoided in any case. If combination with any of these agents is essential, the doctor can reduce the dose of sunitinib to the minimum, with careful control of tolerability.
Drugs that activate the enzyme system lead to faster degradation and thus ineffective dosage of sunitinib. These include the tuberculosis drug rifampicin, the glucocorticoid dexamethasone, the antiepileptic drugs phenytoin, carbamazepine and phenobarbital, as well as St. John’s Wort (for depression). The doctor may increase the sunitinib dosage in cases of unavoidable combination.