Following is information on contraindications to the use of trimipramine in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Trimipramine not be used?
Trimipramine should not be used in case of hypersensitivity to the active substance or to other tricyclic antidepressants.
Because of the risk of mutual enhancement, trimipramine must not be taken with antidepressants from the group of MAO inhibitors. When changing the two active substances, a break of at least two weeks is required.
Treatment with trimipramine is not permitted for the following conditions. These include:
- Acute alcohol or psychotropic poisoning and acute delirium
- conduction disturbances of the heart
- Intraocular pressure increase (glaucoma) or acute angle-closure glaucoma
- bladder emptying disorders with residual urine formation
- severe occlusions or narrowing in the gastrointestinal tract
- severe hepatic dysfunction such as liver inflammation
- severe renal impairment.
Trimipramine should be used only after careful consideration of the benefits and risks followed by close monitoring by the treating physician if the following conditions are present:
- Cerebral spasm readiness (epilepsy)
- Psychosis as well as schizophrenia and paranoid delusions
- Disorders of the heart such as angina, cardiac arrhythmias or heartbeat slowing, as well as a recent heart attack
- low blood pressure
- low blood potassium level
- severe disorders of blood formation
- prostate enlargement.
Co-administration of trimipramine with agents that may cause cardiac arrhythmias or cause a decrease in the level of potassium in the blood should only be given following a doctor’s consultation.
What should you watch out for during pregnancy and lactation?
Trimipramine must not be used during pregnancy and lactation, as the safety of an application has not been established at this time.
What should be considered in children?
The treatment of children under 14 years with trimipramine is not allowed.
Warnings and Precautions
- Blood pressure, heart function, blood count and liver function should be monitored regularly during drug treatment.
- The treatment should be stopped slowly.
- If there is evidence of over-exertion (mania) during treatment, the medication should be discontinued.
- Young patients under the age of 30 years are particularly suicidal despite drug therapy and need to be monitored.
- For epileptics and patients with suspected epilepsy, the brain function must be regularly checked by a doctor (EEG monitoring).
- The drug interferes with responsiveness to the extent that driving a car and driving machinery are dangerous. This is especially true in conjunction with alcohol.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.