What Side Effects Can Trimipramine Have?
Below you will find the most important information about possible known side effects of trimipramine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects: Dry mouth, Tear flow restriction, Tiredness, Drowsiness, Headache, Sweating, Dizziness, Low blood pressure, Blood pressure regulation disorders, Constipation, Weight gain, Elevated liver function (transaminases)
Uncommon side effects:
agitation, sleep disorders, feeling thirsty, hypersensitivity reactions (skin rashes, blood vessel inflammation), urinary problems, sexual dysfunction
Rare side effects:
confusion, collapse, intestinal obstruction, hemorrhage, milk flow, liver dysfunction, alopecia, jaundice, tinnitus, lowering of blood glucose levels, emotional disorders, heart muscle weakness (aggravation), cardiac arrhythmia, delirium, breast formation in men !! !!
Very rare or occasional side effects:
Inflammation of the lungs, coordination disorders (muscular), movement disorders (muscular), allergic skin reactions, seizures (epilepsy), nerve disorders, cataracts, mania
In case of allergic skin reactions or turning the depression into a mania, trimipramine must be discontinued immediately.
If treatment with trimipramine terminates too quickly, withdrawal symptoms such as restlessness, sweating, nausea and vomiting and sleep disturbances may occur. The dosage must therefore be gradually reduced.
What interactions does trimipramine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Trimapramine should not be used with antidepressants from the MAO inhibitor group as the effects increase each other. When changing the active ingredients, a break of at least two weeks must be respected. The mood-reducing effect of sedatives such as benzodiazepines and the depressant effect of alcohol can also be enhanced by combination with trimipramine (abstaining from alcohol during treatment).
The following active ingredients are intensified when they are used together with trimipramine in their effects and side effects. These include:
- Neuroleptics (anti-psychotic agents)
- Remedy for Parkinson’s Disease
- H1 antihistamines (anti-allergy agents)
- Sympathomimetics (agents that affect the unconscious nervous system).
- Antidepressants like Selective Serotonin Reuptake Inhibitors (Fluoxetine)
- Methylphenidate (anti-overactivity agent such as ADHD)
- Disulfiram (active substance against alcohol dependence)
- Cimetidine (gastric fluid from the group of H2 receptor blockers)
- Alprazolam (benzodiazepine agent).
On the other hand, clonidine and guanethidine (hypertensive agents) and certain anti-arrhythmic drugs (quinidine and amiodarone) in combination with trimipramine are attenuated in their action.
Trimipramine is enhanced in its action when taken with the following active ingredients:
On the other hand, barbiturates and the antiepileptic drug phenytoin can accelerate the degradation of trimipramine and thus reduce its effects.