Subutex contraindications and warnings


The following is information on contraindications in the use of buprenorphine in general, in pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should buprenorphine not be used?

Buprenorphine should not be used with:

  • Hypersensitivity to the active substance
  • severe respiratory dysfunction
  • severe liver dysfunction
  • the muscle weakness Myasthenia gravis
  • Taking MAO inhibitors (for depression) during the last 14 days
  • Dependence on opiates or during withdrawal treatment.

Buprenorphine should only be used with the utmost care of the physician:

  • Awareness disorders, psychosis and depression
  • respiratory disorders
  • severe head injuries and increased intracranial pressure
  • Drug and alcohol abuse
  • elderly and debilitated patients
  • biliary diseases
  • renal dysfunction
  • Disorders of the salt balance or hypofunction of the adrenal cortex
  • Blood potassium deficiency and cardiac arrhythmia or when taking antiarrhythmic drugs
  • Thyroid hypofunction (hypothyroidism) and thus partially associated with certain sediment deposits in the subcutaneous and muscle tissue (myxedema)
  • benign prostate enlargement and / or urinary tract narrowing
  • Spinal Bending (Kyphoscoliosis)
  • recent treatment with opiates.

Depending on the area of use and dosage form (drug patch, sublingual tablet, injection) of buprenorphine, the weighting of contraindications (absolute and conditional) may shift. In case of doubt, the doctor should be consulted.

What should you watch out for during pregnancy and lactation?

During pregnancy, buprenorphine should not be used if possible, as there is insufficient experience on the use. Although the animal experiment did not reveal any signs of harm to the unborn child, it can lead to withdrawal and after birth to withdrawal symptoms in the newborn. In addition, the labor activity can be inhibited.

During lactation, the active substance must not be taken, as it passes into the breast milk.

What should be considered in children?

Buprenorphine can be used to relieve pain in children over one year old. The dosage must be individually adjusted to age and body weight.

Buprenorphine may only be used as a drug substitute for substitution treatment from the age of 18, as there is no experience with children.

Warnings and Precautions

  • No alcohol should be drunk during treatment with the drug.
  • The drug is on the Doping List and must not be taken by athletes before or during competitions.
  • The drug is a narcotic that the doctor can only prescribe on a special (Btm) prescription.
  • The drug can lead to habituation and dependency with prolonged use.
  • Treatment with the medication should be stopped at a slowly reduced dose to avoid withdrawal symptoms.
  • Reactivity may be impaired by the drug to the extent that driving and operating machines are dangerous.

Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.