Sotalol contraindications and warnings


The following is information on contraindications to the use of sotalol in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Sotalol not be used?

The active substance must not be used in:

  • Hypersensitivity to sotalol and also antibiotics from the group of sulfonamides
  • severe heart failure, treated heart failure and acute myocardial infarction. Such patients are particularly at risk of suffering further cardiac arrhythmias through sotalol.
  • shock
  • Heartbeat slowing as in blockages of cardiac nerve nodes (AV block II and III degrees, sinoatrial block, sinus node syndrome) and a heartbeat below 50 beats / min.
  • recognizable ECG changes such as a QT prolongation
  • Lack of potassium and / or magnesium in the blood
  • low blood pressure
  • severe circulatory problems in arms and legs
  • Respiratory diseases with bronchoconstriction
  • Metabolic disorders such as metabolic acidosis.

A careful risk-benefit assessment of treatment with sotalol and careful monitoring by the physician should be made at:

  • untreated tumors of the adrenal medulla (phaeochromocytoma). Here should be pretreated with alpha sympatholytic agents.
  • patients with a history of psoriasis or family
  • severe history of hypersensitivity reactions and patients undergoing desensitization therapy for allergies. It can lead to increased allergic reactions.
  • Patients with impaired renal function. You need to get lower dosages.
  • strict fasting and in diabetics with sharply fluctuating blood sugar levels. Medical surveillance prevents unrecognized hypos.
  • Patients suspected of hypothyroidism
  • severe or persistent diarrhea or concomitant administration of medication that results in loss of magnesium and / or potassium. Here, the mineral and the acid-base household must often be controlled by a doctor.

What should you watch out for during pregnancy and lactation?

There is insufficient experience on the use of sotalol during pregnancy. If the mother was treated with soltalol, neonatal heart rhythms, low blood pressure, hypoglycaemia, and respiratory depression may occur. An application should therefore be stopped at least 72 hours before the probable delivery date. If this is not possible, the newborn must be carefully monitored.

During breastfeeding, sotalol may pass into breast milk at different concentrations. Respiratory dysfunction and cardiac arrhythmias are also possible in the infant. If breastfeeding is still required, babies must be monitored for these signs.

What should be considered in children?

Sufficient studies have not been conducted with children to assess the safety and efficacy of sotalol. An application of the drug in this age group is therefore not allowed.

Warnings and Precautions

  • In diabetics, blood glucose levels should be monitored frequently during treatment with the drug.
  • A specific urine test for an adrenal medullary tumor (phaeochromocytoma) may be falsely elevated when using sotalol.
  • The dosage of the drug should not be changed suddenly (slow dose increase, cessation of therapy end).
  • Avoid alcohol during treatment with the drug.
  • In people with allergies, the drug can cause severe allergic reactions.
  • Foods, especially milk and dairy products, can interfere with the absorption of the drug into the body. The medication should therefore not be taken with a meal.
  • The drug reduces the ability to react and thereby the ability to drive and use machines. No work should be done during the treatment without a secure hold.
  • Reducing the flow of tears may affect the wearing of contact lenses.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.