What side effects can Sotalol have?
Below you will find the most important information about possible known side effects of Sotalol.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
anxiety, confusion, mood swings, delusions, increased dreams, depressive moods, dizziness, drowsiness, headache, sleep disorders, nervous sensations, feeling cold on the limbs, blurred vision, hearing impairment, chest pain, low blood pressure, cardiac insufficiency , Heartbeat slowing, palpitations, ECG changes, AV conduction disturbances, cardiac arrhythmia enhancement, cardiac arrhythmia change, loss of consciousness or conditions just before, water retention in the tissues, difficulty breathing, taste disorders, abdominal pain, nausea and vomiting, diarrhea, indigestion, flatulence, Dry mouth, redness, itching, rashes, fever, tiredness.
Uncommon side effects:
conjunctivitis, shortness of breath (in patients with brochienverengenden respiratory diseases), hair loss.
Very rare side effects:
Corneal / conjunctival inflammation, angina pectoris reinforcement, enhancement of circulatory disorders in the arms and legs, conduction disorders in the heart (sinus breakage, blockages at the AV node and His bundle), allergic bronchitis with connective tissue formation, psoriasis -Auslösung.
Side effects without frequency indication:
Reduction of lacrimation (to be considered when wearing contact lenses!), muscle spasms, muscle weakness, potency disorders.
Enhancement of cardiac arrhythmias by treatment with sotalol are possible, this can lead to severe impairment of the heart activity (up to cardiac arrest). In particular, in life-threatening arrhythmia and reduced function of the left ventricle rhythm disturbances can be triggered. Serious side effects of this kind are predominantly dependent on the dosage of sotalol and usually occur early after the start of treatment and when the dose is increased.
What interactions does Sotalol show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Sotalol may cause heart arrhythmia with alcohol or medications that affect the conduction of the heart. These drugs include antihistamines, antidepressants, macrolide antibiotics, probucol (to reduce blood lipids), haloperidol (psychotropic), halofantrine (antimalarial) and antiarrhythmics.
The combination with calcium channel blockers, tricyclic antidepressants, hypnotics (barbiturates, phenothiazines (psychotropic drugs), dehydrators, anesthetics, blood pressure medicines (for example reserpine, clonidine, guanfacine) as well as the Parkinson’s drug methyldopa and with drugs that lead to an increased blood pressure drop dilate the blood vessels.
The medicines norepinephrine (in shock) or MAO inhibitors cause the blood pressure to rise massively.
Co-administration of calcium channel blockers may cause hypotension and cardiac arrhythmias. Also drugs that lead to potassium or magnesium losses (such as the dehydrating agent furosemide, hydrochlorothiazide or others) cause additional cardiac arrhythmia due to these mineral losses.
Cardiac glycosides and muscle relaxants such as tubocurarine are enhanced in their action. The effects of other beta-blockers or antiarrhythmic drugs are also enhanced by sotalol.
The bronchodilator effect of beta-2-sympathomimetics (such as salbuterol, fenoterol, terbutaline, isoprenaline) is attenuated, so their dose may need to be increased.
Along with insulins and hypoglycaemic tablets, sotalol may cause low blood sugar. Together with alcohol and anesthetics it can lead to increased cardiac muscle palsy. When given via the vein, concomitant use of the antihypertensive drug clonidine can lead to a pronounced rise in blood pressure.
A specific urine test for a tumor of the adrenal medulla (phaeochromocytoma) may be falsely elevated when using sotalol.