Seroquel contraindications and warnings


The following is information on contraindications to the use of quetiapine in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should quetiapine not be used?

Quetiapine should not be taken in case of hypersensitivity to this active substance.

Because quetiapine is intensively metabolized in the liver, it must not be co-administered with substances that are metabolized in the same way. These include, for example, antibiotics such as erythromycin and clarithromycin, antifungals such as ketoconazole, HIV-1 protease inhibitors and nefazodone.

Patients with diabetes mellitus, low blood pressure, hepatic impairment, white blood cell count (leukopenia), seizure susceptibility, severe cardiovascular disease or stroke history should only be evaluated with due care taken by risk / reward Doctor treated. Dosage should be as low as possible and regular controls of organ functions and blood counts are essential.

Elderly people with psychotic disorders due to severe dementia should not take this medicine. In this group of people, a positive effect of atypical antipsychotics such as quetiapine is undetectable and the mortality rate during therapy is increased.

What should you watch out for during pregnancy and lactation?

The active substance should not be used during pregnancy and lactation because the safety of the application for mother and child has not yet been established.

Mothers who take the drug in the last trimester of pregnancy endanger their newborns by causing side effects such as movement disorders and withdrawal symptoms. These can be in excitement, muscle tension or flaccidity, tremor, drowsiness, dyspnoea or disturbances in food intake. Such newborns must be carefully monitored by a doctor.

Women of childbearing potential should take contraceptive measures during therapy.

What should be considered in children?

For the treatment of children and adolescents under the age of 18, sufficient studies have not yet been carried out. Therefore, it is not recommended to use quetiapine therapy.

Warnings and Precautions

  • In patients with a previously damaged liver, blood glucose levels should be checked regularly during treatment. It may also be necessary to reduce the dose by the doctor.
  • Before treatment, the blood glucose level and body weight must be determined and treated in the event of worsening during treatment.
  • As a patient, you must be alert for signs of excess blood sugar such as thirst, frequent urination and weakness, and if necessary, notify your doctor.
  • In case of shortness of breath, limited capacity or water retention (edema) in the arms or legs, consult a doctor immediately.
  • Especially during the first period of treatment drowsiness or sudden drop in blood pressure may occur.
  • Responsiveness, ability to drive and use machinery may be impaired.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.