What side effects can quetiapine have?
Below you will find the most important information about possible known side effects of quetiapine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
drowsiness, drowsiness, headache, weight gain, increase in triglyceride levels in the blood, increase in cholesterol, decrease in HDL cholesterol.
Common side effects:
dizziness, accelerated heart rate (tachycardia), liver dysfunction, proliferation of certain liver enzymes in the blood, constipation, nausea and vomiting, runny nose, dry mouth, weight gain, white blood cells (leukopenia), transient hyperthyroidism, Boost your blood sugar.
Uncommon side effects:
Fainting, seizures, involuntary movements such as twitching and tics (dyskinesias), lipid metabolism disorders, type 2 diabetes mellitus.
Rare side effects:
Hypersensitivity reactions (skin rashes, swelling due to fluid leakage from blood vessels (angioedema), itching).
Very rare side effects:
Water retention in tissues (edema), liver inflammation, jaundice, development or marked worsening of diabetes mellitus, persistent and painful erections (priapism), heart muscle disease.
If a malignant neuroleptic syndrome occurs (characterized by muscle rigidity, high fever, clouding of consciousness and circulatory collapse), the treatment must be stopped.
Several cases of acute liver failure have occurred during the treatment with quetiapine since the drug was launched. Therefore, in patients with hepatic dysfunction or previously damaged liver, the doctor should regularly monitor the blood glucose levels during treatment and possibly reduce the dose of the active ingredient.
In individual cases, after taking the active ingredient, there has also been a special change in the blood picture, the so-called thrombotic thrombocytic purpura (TTP). The signs are abdominal pain, reddening of the urine, fever, and evidence of increased bleeding tendency, such as bruises and mucosal bleeding. In such cases, discontinue medication with the active ingredient quetiapine immediately and consult the doctor.
To prevent a metabolic disorder, the doctor will evaluate the appropriate blood levels and body weight at the start of treatment. Deterioration of these values must be dealt with. As a patient you should be aware of signs of increased blood sugar such as increased thirst and increased fluid intake, frequent urination and weakness.
Heart muscle disease can be serious or fatal. If signs of myocardial insufficiency such as shortness of breath, limited exercise capacity or water retention (edema) in the arms or legs appear, the doctor should be contacted and the patient should be examined for myocardial infarction.
What interactions does quetiapine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Antibiotics such as erythromycin, antifungal agents such as ketoconazole, HIV-1 protease inhibitors, other neuroleptics (such as thioridazine) and antiepileptic drugs such as carbamazepine or phenytoin increase quetiapine degradation and decrease its efficacy.
During the treatment no grapefruit juice should be drunk, because the fruit can inhibit the metabolism of the active substance in the liver and increase its effect.
Quetiapine enhances the efficacy of alcohol, benzodiazepines, sedatives, anticholinergics (eg tiotropium), H1-antihistamines, antiarrhythmics, opioid analgesics, tri- and tetracyclic antidepressants, antihypertensive agents and anesthetics.
If MAO inhibitors are taken at the same time, unwanted effects of quetiapine may increase.
At the same time, no substances should be given during therapy which may also lead to a deficiency of white blood cells (for example cytostatics).