Risperdal contraindications and warnings


The following provides information on contraindications to the use of risperidone in general, pregnancy, breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should risperidone not be used?

The active substance must not be used with

  • Hypersensitivity to risperidone
  • Increased concentration of the hormone prolactin in the blood, which is not due to the administration of medication. A possible cause of an increased prolactin concentration is a tumor of the pituitary gland. Signs of this are a feeling of tightness in the chest and a breast enlargement, possibly with a morbid discharge of milk.

The active substance should only be used after careful consideration of the benefit and risk by the physician and under his careful control in patients with

  • Dementia due to evidence of increased mortality
  • to low blood pressure
  • Blood sugar excess (hyperglycemia)
  • impaired kidney function
  • impaired liver function
  • Disruption of blood formation in the bone marrow
  • lack of white blood cells (leukopenia)
  • Epilepsy or a tendency to seizure
  • Parkinson’s disease
  • arrhythmia
  • severe cardiovascular disease
  • tumors whose growth is promoted by the hormone prolactin (for example, breast cancer).

What should you watch out for during pregnancy and lactation?

The active substance should not be used during pregnancy and lactation because the safety of the use for mother and child has not been established. Women of childbearing potential should take contraceptive measures during therapy.

Mothers who take the drug in the last trimester of pregnancy endanger their newborns by causing side effects such as movement disorders and withdrawal symptoms. These can be in excitement, muscle tension or flaccidity, tremor, drowsiness, dyspnoea or disturbances in food intake. Such newborns must be carefully monitored by a doctor.

What should be considered in children?

Children and adolescents with psychosis such as schizophrenia or phases of excessive mania in depression may not be treated with risperidone. There is a lack of experience from clinical studies.

For behavioral disorders, risperidone may be used from the age of five years. However, the doctor must start the treatment with a low dose (0.5 milligrams), which may only be increased slowly. For the duration of treatment, the lowest possible dose should be selected.

Drug treatment should always be accompanied by a social-psychiatric (family) therapy. As with all treatments that only alleviate the discomfort, the continued use of risperidone should be continually evaluated and justified by the physician.

Before risperidone is prescribed for children or adolescents with behavioral disorders, it will fully assess the physician’s physical and social background of aggressive behavior such as pain or adverse environmental conditions. The tiring effect of risperidone may affect the ability to learn in this patient group. A change in the intake time can then improve the influence on the attention of children and adolescents.

Risperidone should not be used for the treatment of children under the age of five.

Warnings and Precautions

  • Especially in the elderly, care must be taken during hydrotherapy to ensure adequate hydration and a balanced water and mineral balance.
  • If signs of stroke occur during treatment, such as unclear language, sensory disturbances, paralysis, vision problems, seek medical attention immediately.
  • Patients with diabetes or severe obesity must regularly check their blood sugar during treatment.
  • From time to time the doctor should check if existing anti-Parkinsonian treatment is still necessary.
  • Sports, fever, or lack of hydration during treatment can cause a fever.
  • If you experience fever, muscle stiffness, dizziness and loss of consciousness during treatment, consult your doctor immediately.
  • Treatment with the drug must always be stopped (“swollen out”) with slowly diminished doses.
  • Responsiveness, ability to drive and use machines may be compromised.
  • Especially during the first period of treatment drowsiness or a sudden drop in blood pressure may occur.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.