Remicade contraindications and warnings


The following provides information on contraindications to the use of infliximab in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When can infliximab not be used?

The active substance should not be used at:

  • Hypersensitivity to infliximab
  • tuberculosis
  • severe infections, purulent diseases and severe organic diseases
  • moderate or severe heart failure (heart failure)

Only after a careful benefit-risk assessment by a physician, the drug may be used in:

  • mild heart failure
  • severe neurological disorders such as multiple sclerosis
  • Patients with joint replacement
  • Narrowing in the gastrointestinal tract due to Crohn’s disease (inflammatory bowel disease)
  • History of malignant diseases (cancers)
  • Patients with psoriasis when a highly immunosuppressive treatment has preceded
  • old people
  • pre-existing liver and kidney damage.

What should you watch out for during pregnancy and lactation?

Infliximab is believed to weaken the infant’s immune system. Therefore, the drug must not be taken during pregnancy. Women of childbearing potential must use reliable contraception and should continue to use contraception for at least six months after the last infliximab treatment.

Also, breast-feeding must not be stopped for at least six months after the last infliximab treatment.

What should be considered in children?

The use in children is only allowed in the field of chronic inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. Allergies are recommended for treatment with the active substance only from the age of six years.

Warnings and Precautions

  • If surgery is required, the patient should be monitored carefully because of the risk of infection.
  • The drug may also trigger delayed allergic reactions that must be reported to the treating physician immediately.
  • If a serious infection develops during treatment with the drug, treatment should be stopped immediately.
  • During treatment with the drug, live vaccines should not be given at the same time (in children: no vaccines at all).
  • Treatment with the drug should be left to physicians specializing in rheumatic and psoriasis.
  • Dizziness can occur after using the medicine, making driving a car and operating machinery dangerous.

Sometimes medications release allergic reactions.
If you notice signs of allergic reaction, tell your doctor or pharmacist immediately.