What side effects can infliximab have?
The following is the key to the possible known side effects of infliximab.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
fever, shortness of breath, chills, hives, high or low blood pressure.
Common side effects:
Viral infections (eg, herpes, influenza), upper respiratory tract or lung infections (bronchitis, pneumonia, sinusitis), fatigue, shortness of breath, nausea, abdominal pain, diarrhea, dry skin, increased sweating, Chest pain, temporary flushing of the face, elevation of liver function.
Uncommon side effects:
Bacterial infections, fungal cavities, respiratory allergic reactions, laryngeal swelling with dyspnea, anemia, seizures, depression, confusion, nervousness, insomnia, somnolence, fainting, palpitations, cardiac arrhythmia, ocular inflammation, hot flushes, hepatic dysfunction , Gall bladder inflammation, inflammation of the bladder, blue discoloration of the skin, skin changes (eczema, dandruff, blistering, purulent pimples, discoloration (pigmentary anomalies), bleeding into the skin), inflammation of blood vessels, bruising, constriction of blood vessels by spasms of the vascular musculature resulting circulatory disorders, lymph node swelling, proliferation of lymphocytes, nosebleeds, constriction of the bronchi, pleurisy, water retention in the lungs, constipation, heartburn, inflammation of protrusions of the colon (diverticulitis), urinary tract egsinfections, pyelitis, inflammation of the vagina.
Rare side effects:
meningitis, circulatory failure, palpitations, intestinal obstruction, intestinal perforation, bleeding from the gastrointestinal tract, demyelinating disease of the nervous system, other nerve diseases (for example, inflammation of the optic nerve), meningitis, seizures, numbness, tingling, severe infections with fungi and bacteria, allergic shock, pancreatitis, hepatitis, water retention between the pleura and lung, muscle, joint and back pain.
Very rare side effects:
Liver cell damage, pericardial effusion, dissolution of red blood cells (hemolytic anemia), reduction of platelets (thrombocytopenia), reduction of white blood cells (granulocytopenia, leukocytopenia) and inflammation of the spinal cord (myelitis). !!!
In rare cases seizures and inflammation of the optic nerve occur. The first onset of multiple sclerosis (demyelinating disease, predominantly the white matter of the central nervous system) or aggravation of already existing multiple sclerosis has been observed.
Patients with mild heart failure should be strictly controlled by a physician. In case of deterioration, the active substance must be discontinued.
A small proportion of patients produce antibodies to infliximab. It can lead to severe allergic reactions to shock.
Deficiency of TNF may favor the appearance of antibodies to the body’s own tissues. If such antibodies are detected in the blood or a patient already shows signs of disease, the treatment must be stopped.
What interactions does infliximab show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Serious infections occurred with concomitant administration of other TNF-blocking agents, such as etanercept and anakinra.
There are indications that methotrexate reduces the formation of antibodies to infliximab. At the same time, the infliximab concentration in the blood plasma seems to increase in interaction with methotrexate. However, the determination of infliximab and its antibodies in the blood is too imprecise to prove this interaction.
Live vaccines should not be given during therapy with infliximab. It is questionable if immunosuppressive treatment could even respond to a vaccine. In addition, due to the weakening of the immune system infections by the live vaccines are conceivable.