What side effects can Ramipril have?
Below you will find the most important information about possible, known side effects of Ramipril.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
dizziness, weakness, visual disturbances (rarely with loss of consciousness without apparent cause), renal dysfunction (rarely to kidney failure), dry cough, bronchitis, nausea, abdominal discomfort, indigestion, headache, fatigue, drowsiness, decreased concentration of red blood pigment.
Uncommon side effects:
excessive blood pressure reduction, reduction in all blood cells, reduction in white blood cell counts, platelet reduction, prolongation of conduction time and conduction failures of the atrium and ventricle (AV block II and III degrees) on the ECG, blood pressure drop, protein excretion in urine (sometimes with impaired kidney function), shortness of breath, runny nose, sinusitis, vomiting, diarrhea, constipation, loss of appetite, pancreatitis, allergic skin reactions with redness and itching.
Rare side effects:
loss of consciousness, fainting without apparent cause, worsening kidney function, nasal mucosal inflammation, vascular swelling with involvement of the lips, face, larynx and / or arms and legs, drowsiness, depression, sleep disorders, impotence, skin discomfort, balance disorders , Confusion, tinnitus, blurred vision, changes in taste, transient loss of taste, anemia, reduction in platelet count, neutrophil deficiency and eosinophilic blood cells (special cells of the body), increased blood urea, blood creatinine increase, blood potassium increase, sodium deficiency in the blood, cardiac shock, increased skin blistering, incipient Jaundice (biliary obstruction) to liver cell death possibly with fatal outcome (unclear connection to the use of ramipril), hives, skin rash with severe disturbance of the general condition.
Very rare side effects and isolated cases:
palpitations, cardiac stumbling, chest pain, cardiac arrhythmia, chest tightness, heart attack, cardiac sensation, precursors of stroke, stroke, acute renal failure, airway muscle spasm, allergic lung disease and pneumonia, tongue inflammation, dryness Mouth, liver inflammation, hepatic dysfunction, intestinal obstruction, serious skin lesions, fever, muscle pain, joint pain, arthritis, inflammation of the vein, increase in white blood cells, increased ANA titer (antibody content), psoriasis-like lesions, vesicular lesions, skin reactions, skin rash, photosensitivity, hair loss , Nail detachment, seizures caused by vascular convulsions, reduced blood flow to the fingers (Raynaud’s symptoms), increased blood bilirubin concentration, liver enzyme increase, liver dysfunction, Mang el granulocytes (special cells of the body’s defense), deficiency of all blood cells (especially in patients with impaired renal function, connective tissue diseases or concomitant therapy with the uric acid-lowering drug allopurinol, the heartbeat-regulating drug procainamide or certain drugs that suppress the defense reactions), blood potassium increase in diabetes, Breast augmentation, eradication of red blood cells with anemia, increased erythrocyte sedimentation, dissolution / decay of red blood cells, increased sweating.
Patients with heart failure may lose a lot of blood pressure during treatment. This would result in decreased urine output, blood acidity, kidney failure, and possibly death. Therefore, these patients must be monitored very carefully by a doctor.
Especially with pre-existing gallstones, acute gall bladder infection can occur.
In patients with renal impairment, the blood levels of urea, creatinine and potassium may increase and the concentration of sodium in the blood may drop. Blood values should therefore be checked before treatment and regularly during treatment.
If a serious skin reaction is suspected, seek immediate medical attention. Therapy discontinuation may be required.
If jaundice or significant increase in liver enzymes occurs, therapy with the ACE inhibitor must be discontinued. The attending physician is individually over an alt
What interactions does Ramipril show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Immunosuppressants increase the risk of developing blood cell abnormalities. Allopurinol (anti-gout remedies), cytostatic drugs (anti-cellulite), glucocorticoids and procainamide (anti-arrhythmic agents) further potentiate these changes in the blood count. Therefore, the attending physician should regularly check the blood count.
Combination with antihypertensives such as AT1 receptor antagonists or aliskiren is not recommended as it increases the risk of side effects such as potassium deficiency, hypotension and decreased renal function. This is especially true in patients with kidney dysfunction due to diabetes.
Non-steroidal anti-inflammatory drugs (cortisone-free anti-inflammatory analgesics) and saline reduce blood pressure. Anesthetics and antihypertensives, on the other hand, increase blood pressure. That’s why frequent blood pressure checks are required in these cases.
In addition, potassium supplements and potassium-sparing dehydrating agents (such as spironolactone, amiloride, and triamterene) as well as potassium-causing drugs (such as heparin) increase potassium levels. Therefore, regular medical laboratory checks are recommended.
A combination of ramipril with lithium (psychotropic drugs) is not recommended, as the elimination of lithium is delayed. Then very strong side effects are to be expected.
Polyacrylonitrile-methallylsulfonate-high-flux membranes (used in dialysis), dextran sulfate (used in blood fat purification, LDL apheresis) and insecticidal toxins in a desensitization therapy increase the risk of allergic reactions to shock , These patients must be monitored very carefully by a doctor.
In addition, concomitant administration of ramipril and oral hypoglycaemic agents and insulin increases blood sugar reduction. That’s why regular blood glucose checks are required. The dose should be adjusted individually by the attending physician.
In addition, care should be taken to increase the effects of alcohol when ramipril is co-administered. Therefore, should be dispensed with during the treatment on alcohol consumption.