What Side Effects Can Propranolol Have?
Below you will find the most important information about possible known side effects of propranolol.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Fatigue, dizziness, drowsiness, headache, confusion, nervousness, sweating, insomnia, depression, nightmares, hallucinations, discomfort, gastrointestinal discomfort, nausea and vomiting, constipation, diarrhea, drop in blood pressure, heart stumbling , Cardiac insufficiency, cardiac insufficiency, skin reactions, redness, itching, rashes, hair loss.
Uncommon side effects:
Muscular weakness (myasthenia gravis-like), dry mouth, lacrimation, conjunctivitis, blood count changes (platelet reduction), skin bleeding.
Very rare side effects:
enhancement of existing myasthenia gravis, angina pectoris enhancement, discomfort enhancement, psoriasis, psoriasis enhancement, combined corneal inflammation and conjunctivitis, blurred vision, joint pain, diabetes mellitus, increased liver function, Libido reduction, impotence, in existing kidney disease: kidney function deterioration.
The beta-2 effect can lead to a narrowing of the respiratory tract and therefore to shortness of breath, especially in patients with a sensitive bronchial system, for example in asthma.
In patients with Hyperthyroidism can mask the symptoms of rapid heartbeat and tremors. After prolonged severe fasting or heavy exercise, it can lead to low blood sugar, in addition, disorders in fat metabolism can occur.
What interactions does propranolol show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
When used concomitantly with insulin or other agents for the treatment of diabetes, propranolol may increase or prolong their effects. Warning signs of hypoglycaemia such as palpitations and muscle tremors (tremor) can be so mitigated that they are no longer recognizable as signs of disease (obfuscation). Therefore, regular blood sugar checks are required.
Propranolol may increase the effect of other antihypertensive agents and therefore lead to excessive blood pressure drop. This applies, for example, to the use with other beta-blockers as well as with tri- and tetracyclic antidepressants, sleeping pills (barbiturates), active substances for water excretion (diuretics), vasodilators, anesthetics and nitroglycerin. Similarly, propranolol may potentiate the action of anti-arrhythmic (antiarrhythmic) agents.
Combining propranolol with cardiac glycosides and brain-lowering antihypertensive agents such as reserpine, methyldopa, guanfacine and clonidine may result in a greater decrease in heart rate and delay in cardiac conduction.
Concomitant administration of propranolol with the stress hormones norepinephrine or epinephrine may cause a very rapid and rapid rise in blood pressure. In MAO inhibitors (for depression), the same effect is caused by the reduced degradation of propranolol HCl. Also, the intake of cimetidine from the group of H2-receptor blockers enhances the action of propranolol.
Indomethacin from the group of non-steroidal anti-inflammatory drugs may reduce the blood pressure-lowering effect of propranolol.
In the event that propranolol can not be discontinued before surgery under anesthesia or prior to the use of muscle relaxants (for example for artificial respiration), the anesthetist must be informed of the treatment.