Following is information on contraindications to the use of Propofol in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Propofol not be used?
Propofol should not be used in patients with hypersensitivity to the active substance.
Only after careful medical benefit-risk consideration and with particular care may the active substance be used in
- Patients with cardiac, respiratory, renal or hepatic impairment
- elderly and those in poor general condition
- lack of blood
- impaired consciousness
- Epilepsy in Prehistory
- increased intracranial pressure with low blood pressure, as there is a risk of a significant reduction in intracranial pressure.
What should you watch out for during pregnancy and lactation?
The safety of the use of propofol during pregnancy has not been established by studies. Therefore, Propofol should only be used during pregnancy if the doctor considers it essential. Propofol penetrates the cake and can affect the respiratory and cardiac function in the newborn. Extra high dosages (more than 2.5 milligrams propofol / kilogram of body weight for induction of anesthesia or 6 milligrams propofol / kilogram body weight / hour to maintain anesthesia) should be avoided.
Studies in nursing mothers showed that propofol passes into breast milk in small amounts. Therefore, mothers should discontinue breast-feeding and discard breast-milk for 24 hours after using Propofol.
What should be considered in children?
The use of Propofol for general anesthesia (anesthesia) in children under one month is not recommended. The use of Propofol for reassurance in investigations or minor surgical interventions in children and adolescents aged 16 years and younger, the doctor will decide individually, since the safety and effect are not adequately substantiated by studies.
There are reports of serious side effects of improper use of propofol to immobilize patients under the age of 16, even deaths. In particular, metabolic acidosis (metabolic acidosis), lipid metabolism disorders, muscle destruction (rhabdomyolysis) and / or heart failure were noted. These were most commonly reported in children with respiratory infections who received higher doses than those recommended for adult intensive care. However, a connection with the propofol administration was not definitively secured.
Warnings and Precautions
- The drug should not be used as part of an electroshock treatment.
- For severely overweight patients, more side effects on the cardiovascular system must be expected due to the higher dosage required.
- The drug should not be used in children under one month of anesthesia.
- For children under the age of 16, use for immobilization is at the discretion of the physician.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.