What side effects can Propofol have?
Below you will find the most important information about possible known side effects of Propofol.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
Pain at the site of the first injection.
Common side effects:
fat metabolism disorders (blood triglyceride excess).
During anesthesia induction: spontaneous and muscle twitching, excitement, drop in blood pressure, slow heartbeat, rapid heartbeat, flushing, panting, temporary respiratory arrest, cough, hiccup. !!!
Uncommon side effects:
pronounced fall in blood pressure, slower heartbeat with increasingly severe course (cardiac arrest) under general anesthesia, cough while maintaining anesthesia.
Rare side effects:
Severe hypersensitivity reactions (facial swelling, bronchospasm, erythema and drop in blood pressure), discoloration of urine (after prolonged administration of propofol), fever (after surgery).
In the recovery phase: Overachievement, reduction of sexual inhibition, headache, dizziness, shivering, feeling cold, epileptic seizures including spasms of the back, cardiac arrhythmia, cough, nausea or vomiting.
At the injection site: blood vessel obstruction and phlebitis.
Very rare side effects:
Epileptic seizures (delayed by hours to a few days), convulsions (in epileptics), unconsciousness (after surgery), accumulation of water in the lungs, pancreatitis, tissue destruction (after accidental administration next to the vein), muscle dissolution (rhabdomyolysis), metabolic acidosis (metabolic acidosis), blood potassium excess, heart failure (in some cases fatal).
Significant hypotension may require slower administration of propofol and / or the use of blood substitutes as well as vasoconstricting agents. The possibility of a significant drop in blood pressure should be considered in patients with circulatory disorders of the heart or brain or in patients with a lack of blood.
In isolated cases, unconsciousness may occur after the operation, which may be accompanied by increased muscle tension. Their occurrence is independent of whether the patient was awake or not. Although the consciousness is regained spontaneously, the unconscious patient is kept under close medical observation.
A pronounced slowing of the heartbeat will be counteracted by the physician before initiation or during the maintenance of anesthesia with appropriate active ingredients.
What interactions does Propofol show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Propofol may be used with other agents used in anesthesia (for pretreatment, narcosis, analgesics, muscle relaxants, local anesthetic). Serious interactions with the said agents have been known so far. Some of these substances acting on the brain can attenuate the respiratory and circulatory functions, which is a dangerous increase in the effects of Propofol.
Lower doses of Propofol may be required if general anesthesia is associated with local anesthesia.
Co-administration of benzodiazepines, parasympatholytics and anesthetic gases results in prolonged anesthesia and slower breaths. Additional pretreatment with opioid analgesics may increase and prolong the sedative effect of propofol, and respiratory arrest may increase and be prolonged in time.
It should be noted that propofol’s cardiovascular system’s anti-analgesic effects and side effects are compounded by concomitant use of pre-treatment agents, anesthetic gases or analgesics. The simultaneous administration of substances with effect on the brain (such as alcohol, anesthetics, opioid analgesics) leads to an increase in their sedative effects.
If Propofol is combined with agents that reduce brain activity, a significant reduction in the functions of the heart and respiration is to be expected. After administration of fentanyl (opioid analgesic) there may be a temporary increase in the blood level of propofol and associated respiratory arrest.
After treatment with suxamethonium (muscle relaxant) or neostigmine (to relieve the muscle relaxant effects of muscle relaxants), heartbeat and cardiac arrest may occur.