About Promethazine

3.5 rating based on 59 ratings
Rating: 3.3 Reviews: 59
About Promethazine

Promethazine is used differently due to its diverse mode of action.

What is the purpose of this ingredient?

  • Restlessness and agitation as well as anxiety disorders in psychiatric disorders (psychoses) dampen
  • allergic reactions such as watery eyes, runny nose or asthma attacks with shortness of breath, rash, redness and itching of the skin and suppressing diarrhea in allergies
  • reduce nausea, vomiting, and sleep disturbances
  • Reduce anxiety and tension before surgery

How promethazine works

Below you will learn more about the fields of application and the mode of action of promethazine.
Please also read the information on the drug classes H1-antihistamines, neuroleptics, antiallergic drugs, to which the active ingredient promethazine belongs.

Areas of application of the active substance promethazine

Promethazine is used differently due to its diverse mode of action.

On the one hand, it is prescribed for allergic diseases (allergies) to suppress allergic reactions such as watery eyes, runny nose or asthma attacks with shortness of breath, rash, redness and itching of the skin as well as diarrhea.

On the other hand, promethazine is used for basic psychiatric disorders (psychoses), in particular for the relief of agitation and agitation or anxiety disorders. Promethazine can be administered in this context as a single agent or in combination with other drugs from the group of psychotropic drugs.

Promethazine’s soothing and calming action is also used for anesthesia preparation to relieve the patient of the fear of surgery.

Ultimately, the drug can also be used to treat nausea and vomiting or sleep disorders. However, for this purpose, less side-effect-rich therapeutic trials should be undertaken beforehand.

For the following application areas of Promethazine , in-depth information is available:

  • Nausea and vomiting
  • sleep
  • allergy
  • psychosis
  • anxiety disorders

How promethazine works

The active substance promethazine is a H 1 antihistamine with a strong soothing (sedative) effect. It is therefore mainly used as a means of treating allergies and as a sedative (sedative) for the relief of sleep disorders use.

The messenger histamine triggers the symptoms that occur in an allergy. Mostly it is inflammatory complaints (watery and itchy eyes, redness and itching of the skin, runny nose, but also diarrhea). Histamine is transported via the bloodstream to different regions of the body. Promethazine occupies the binding sites of the histamine (H1 receptors) in the body. As a result, the histamine can no longer develop its effect in the body and the allergic reactions remain. Promethazine also occupies the binding sites in the brain. This makes it reassuring and sleep-inducing.

Promethazine continues to be able to inhibit the effect of the body’s own messenger dopamine. Therefore, it is simultaneously assigned to the weakly effective neuroleptics. Due to its dopamine-inhibiting effect restlessness and anxiety disorders, as they often occur in connection with a psychosis, dampened.

Promethazine stimulates salivation and intestinal activity via its influence on the messenger acetylcholine, which is why it can be used effectively for nausea and vomiting.

Potential Promethazine side effects may include:

Promethazine used to treat the following diseases:

  1. Evelyn R. Hamer says:
    4.0 rating

    Promethazine for Sleep disorders

    I can not say too much, it’s the second attempt. I had taken Doxepin 10 mg 2 years for anxiety disorders with sleep-disorder, wanted something else since I had 20 kg increased by Doxepin. So I dropped Doxepin from one day to the other and got a Promethazine 25 in the afternoon. There was no talk of sleeping, I felt like my heart was beating, I was restless, panicked. The next day I immediately called my doctor and told her. She then said that I had dropped the doxepin too suddenly. Maybe, you should rather sneak out. She then prescribed me Doxepin again and I took it again for a while and reduced it to a half, so 5 mg. For sleeping I found it very good, only the weight gain. But I still had the Promethazine and started to divide the 25s into four pieces, one of them. I’ll just see how they get me, because as I read here, they are against sleep disorders. Perhaps the restlessness was due to the discontinuation of doxepin. Incidentally, I also take 40-50 drops of tilidine because of a pinched nerve. Whether that will work, I have to try. But I will, if again, then prescribe drops of promethazine, because I can dose the better.

    Side effects: Palpitations; Unrest
  2. Jeanette M. Irby says:
    3.5 rating

    Promethazine for Depression; Sleep disorders

    At the beginning, I tolerated everything super well, until I noticed that I have gained a great deal in less time, cravings, sweating in small work, heart races. In any case, I slept great and was in the morning again quickly fit, not as Doxepin since I was still totally in the morning next to the track. The kilos started to bother me so much that I only put it off on medication. I stopped taking them hoping to eat less again. Which was true, but I do not sleep at night anymore. It is not my body resting but that is not sleep, you hear everything and that is not a restful sleep. Especially not with two children. I’m afraid to access the drugs again because otherwise I’ll get up like a yeast cake. About 25-30 kilos in the months. That’s why my question also make these drugs dependent? What can you do that is a cycle from which one does not come out so easily.

  3. Sarah S. Gary says:
    3.5 rating

    Unbearable tiredness, would almost fall asleep standing, could hardly keep me on my feet, just lay in bed, did not get out in the morning. And that at only 25 mg! Muscle twitching all over my body, which in the end I was not able to sleep in spite of somnolence, because I was constantly frightened by the convulsions. The whole body jumped. Weight gain, increased heart stumbling. Not a good substitute.

  4. Karen G. Bogard says:
    2.0 rating

    Promethazine for Sleep disorders

    I take promethazine Neuraxpharm for about 1 month against sleep disorders and take them after use. Say, really only if I have strong sleep problems. Unfortunately, I get through the night twitching, which rob me even more sleep or even wake. the unpleasant feeling also runs through the day. I will therefore no longer take the drug.

    Side effects: Muscle twitching
  5. Georgeanna R. Alexander says:
    2.0 rating

    Promethazine for Sleep disorders

    Since I get this medication, I suddenly start to twitch at night, I can not help it and sometimes I get really panic. In addition, I dreamed at the beginning of the intake, so before the drug level had stopped, not at all (as far as I know) and now it’s more like before the first intake, I dream again and through this kind of dreams, I get anxiety again … I do not know if it makes so much sense to raise the medication dose … at the moment I take 25mg Promethazine …

  6. Linda B. Thompson says:
    2.5 rating

    Promethazine for Depression; Sleep disorders

    I have side effects with promethazine. As soon as I get tired, my legs start to go crazy, so sleep is out of the question and I have to get out of bed.

    Side effects: Restless legs
  7. Donald L. Dotson says:
    3.5 rating

    No rose without thorns … In 1996 I noticed that Atosil (promethazine) with about 80 pots once helps against anxiety attacks very well. Strong coffee helps against drowsiness. Citalopram is a very potent drug and initially has very strong side effects. Already at 10mg at the beginning I had a strong drop in blood pressure, so I did not dare to go outside for three days. Unfortunately, the smallest strength is 10mg, the first few days you should start with 5mg / day. Even when weaning you should get withdrawal symptoms. First, I got from the cita an aqueous bowel movement (no diarrhea), dizziness and dry mouth. It stayed that way a bit. Also with me an indifference against female stimuli adjusted (libido loss). Furthermore, there were: water retention in the legs (on the other hand, diuretics like torasemide help to gain weight (eat a lot of vegetables and lean quark), my age-related distance vision has increased. I take 40mg cita a day now. , 400mg amisulpride and 20mg torasemide / day. And very strong Kafee …. These are my experiences. This can be different for everyone and you have to try it out. Good luck and courage, you have to go through but it helps. Stefan

  8. Stella D. Johnson says:
    4.0 rating

    Promethazine for Sleep disorders

    So, now I would like to share my experiences, because something incredible happened to me. For some months I have been using promethazine because I could not sleep well and was too agitated. The drug helped me a lot. I quickly fell asleep and was not smashed the next morning either. Side effects include water retention and weight gain. This can only happen sometimes, but I got a little headache after taking the drug for a long time and I have gained a lot of weight. In the last two years, I have lost 25 kg through diet and exercise. After Christmas I had about 7 – 8 kg back on it. At first I thought that was related to Christmas and I was motivated and changed my diet again and went back to sports regularly. I could do whatever I wanted, I always had a weight. Whether I was at sports, that did not matter. I was really desperate and then went to my doctor. She took blood from me and also examined urine. It was all great, so that a metabolic disorder or thyroid disease could be ruled out. I then told her my suspicions about Promethazine, but she did not want to hear that. I then discontinued the drug on my own, since I should only take it if necessary anyway. The first 7 days did not happen, but then it started. I had to go to the bathroom so often and for weeks, so I lost almost 4 kg in the first week alone. Now begins the second week and I was now (10:31 clock) 14 times on the toilet. So if you have these problems, it could be that you also have water in it.

    Side effects: Water storages
  9. Lois B. Brown says:
    3.5 rating

    I started on 15 drops of promethazine at bedtime. Although I quickly fell asleep, but got in the night quite restlessness in the legs, so that I could not sleep. Anxiety in the heart area was added. The next morning I was blown away and felt beside the track. I tried again with lower dosage, whereupon my soul did not react. Instead of strengthening me from the outside, so with the use of this drug, I now use movement, ie gymnastics, conditional Sträining, and breathing techniques, which I practice now every evening for 1/4 hrs long. It does require discipline, but it helps and it has good side effects. For example. The shape and posture of my body has improved, which also affects my stress resistance. Conclusion: This drug has moved me a lot during the night and made me motionless during the day. I can really only recommend internally activated exercise therapy for people who suffer from anxiety. So a strong soul lives in a strong body (…) 🙂

    Side effects: Restless legs; Hangover
  10. Earl G. Pond says:
    2.5 rating

    Promethazine for Sleep disorders

    Initially slight drowsiness during the day. Otherwise well tolerated. With 25-30 drops, or 2 to 3 tablets, I have the best experience, which corresponds to about 25-30mg active ingredient. At higher doses the daytime fatigue was very pronounced the next day.

    Side effects: Hangover; Dizziness
  11. Robert L. Chapman says:
    4.0 rating

    Promethazine for Sleep disorders

    I was prescribed the drug because of sleep disturbances after taking citalopram. The medication is 25mg if needed. Approximately To go to bed 30 minutes before. I can sleep very well with the tablets. The morning after, you still have mild twilight states at first, but nothing bad. The more frequently the intake takes place, the fresher and more relaxed one feels. I could not find any side effects until now.

    Side effects: Hangover
  12. Kent K. Kumar says:
    4.0 rating

    Promethazine for Depression; Sleep disorders

    As a side effect, moclobemide results in mild, unrestricted vision disorders, mild, unrestricted vision problems, sleep disorders. In this case, since the previous discontinuation of venlafaxine (in the long term to serotonin syndrome) the effect of moclobemide was not allowed to be too good, d. H. In the long term not too much serotonin remains in the brain, 200 mg instead of 300 mg would be ideal. Compared to many incompatible SSRIs, moclobemide proved to be significantly more effective. Promethazine neuraxpharm 25 mg was taken to correct the sleep disorders and corrected them well. As side effects of promethazine neuraxpharm occur loss of appetite (desire for sex) and premature ejaculation on. Depression is one of the very few sources of stabilizing the disease in the natural way, so depressive problems are particularly detrimental.

  13. Manuel J. Pyron says:
    4.5 rating

    Promethazine for Social phobia; Obsessive compulsive disorder; Sleep disorders

    After four months, my third report on Sertraline. Correct statements on effects and side effects can only be made after a longer period of use. After gradual dose increase I take 150 mg daily for about two months. Side effects have significantly reduced after a while. The only side effects that are worth mentioning for me are sleep disorders, which also occurred only after a dose of 100 mg. Previously I was able to sleep well with the Sertralin. For sleeping, therefore, I take promethazine drops (so 20-30 mg daily). I’m fine with this station wagon now. The Sertralin prepares a fairly constant good mood. Thoughts, social fears, fears of expectation and future fears have improved significantly, the distance to the constraints and to the everyday problems has increased. Since it is about the mirror, I do not immediately feel that I take a medi. Sertraline does not quench (on the contrary it causes the sleep disorder) and improves the ability to concentrate. No weight gain.

    Side effects: Sleep disorders
  14. Jill A. Bassler says:
    3.5 rating

    Promethazine for Sleep disorders

    I got them prescribed so I could sleep better … Within a few minutes, I had sweats, shaking all over, anxiety. ..herzrasen, pulse is rapidly rising and falling. .. So bad that my mum has called the ambulance … In the end it was a hyperventilation And have been struggling with the seizures for three days!

  15. Sheena J. Tyson says:
    4.0 rating

    Promethazine for Post-traumatic stress disorder; Anxiety disorders

    I’ve been taking 15 drops of promethazine neuraxpharm every night for 2 weeks now and I do not have much to complain about. A slight libido loss that you can get over. It’s a little harder to get out of bed in the morning, but it settles down quickly. And my appetite is much higher, but with a bit of discipline, that’s not a problem either. If I do not take the drops, I get strong night terrors, with hallucinations, nightmares and fainting, due to an early childhood trauma. But when I take them, I quickly become so calm that I can go to bed as normal as I can, without any fear! That’s why I’m so excited about the drug. It saves my life every night, if you will. Can only recommend it.

  16. Charles M. Kelly says:
    3.0 rating

    Promethazine for Sleep disorders

    Lorazepam: Great effect … can only get by with Tavor. No side effects but tolerance (from 2.5mg increased to 7.5mg) Promethazine: Hardly any side effects and in combination with Tavor and 2-3 beer a good sleep aid Cipralex: Total loss of libido, otherwise no side effect …. but also no Effect.

    Side effects: Libido loss
  17. Robbie B. Collins says:
    4.5 rating

    Promethazine for Sleep disorders

    I have prescribed this medication for sleep disorders and anxiety. The drug was easy to dose as I got it in drop form. However, I only tolerated it badly (despite the low dosage of about 20mg) because I got restless legs and became restless, so I could not fall asleep. On the second evening self-destructive thoughts were added, which I found difficult to distance myself from. At the same time mood depressions surfaced, which I had not had in this form for some time. I dropped it off for my own safety.

  18. Jewell M. Kirk says:
    2.0 rating

    Promethazine for Depression; Sleep disorders

    I am 49 years old, have depris and fibromyalgia. Should take because of both diseases Cymbalta. It looks great, has a lot less pain and I’m not so close to everything anymore. I am much calmer. However, I sleep very badly and often sweat as mad. Always look blurry and can read badly. I do not know if it’s related to the pills or my age. To fall asleep I take Promathezin it helps me very well. My big problem I’ve gained 5 kg, which then makes me Depris. I’m not slim anyway. I do sports 2-3 times a week and watch the food, but nothing happens.