Priligy is intended only for men with premature ejaculation. The safety of the drug in men without premature ejaculation is not established, there is no data on ejaculation delay. A randomized, double-blind, placebo-controlled study confirmed the efficacy of Priligy for the treatment of premature ejaculation (PE). Priligy 60 mg significantly improves the average time of intravaginal ejaculation delay (IELT) compared with Priligy 30 mg in men with lifelong PE, but there is no difference in men with acquired PE. Dapoxetine increases the sense of control and sexual satisfaction in men from 18 to 64 years of age with PE.
Side effect of insomnia; fatigue; anxiety; restlessness; unusual dreams; depression; a state of euphoria; mood changes; nervousness; indifference; apathy; sleep disorders; nightmares; decreased libido; loss of libido; anorgasmia; violation of concentration of attention; fainting, incl. vasovagal syncope; postural dizziness; perversion of taste; lethargy; oppression of consciousness; blurred vision; pain in the eye area; tinnitus; sinus bradycardia; tachycardia; a decrease in blood pressure; systolic hypertension; nasal congestion; yawn; nausea, vomiting; diarrhea, constipation; abdominal pain; dyspepsia; flatulence; bloating; dry mouth; itching; cold sweat; erectile disfunction; absence of ejaculation; violation of orgasm, incl. anorgasmia in men; paresthesia of male genital organs; irritability; feeling of heat; feeling of intoxication.
The combination of Priligy with alcohol can enhance the effect of the drug on the central nervous system and neuro-cardiogenic side effects of alcohol, for example, syncope, which increases the risk of accidental injury. Therefore, patients should be advised to refrain from drinking alcohol during the period of taking Dapoxetine.
There is evidence that abrupt withdrawal of SSRIs, long-term use for chronic depression, leading to the following symptoms: depressed mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesia a sensation of electric shock), anxiety, confusion, headache, lethargy, emotional instability, insomnia, hypomania. In a clinical study to evaluate the effect of drug withdrawal Priligy 62 days after receiving a dose of 60 mg (daily or on demand) in patients with premature ejaculation, revealed no signs of withdrawal. After the transfer of patients on placebo after daily dosing Priligy detected only minor withdrawal symptoms of mild or moderate insomnia and vertigo. Similar results were obtained in another clinical trial with double-blind control with a weekly evaluation period of withdrawal effects after 24 weeks of drug use at a dose of 30 mg or 60 mg as needed.