Priligy (Dapoxetine)

3.5 rating based on 9 ratings
Rating: 3.6 Reviews: 9
Priligy (Dapoxetine)

Priligy influences the ejaculation reflex, increasing the latent period and decreasing the duration of reflex impulses of the motoneurons of the perineal ganglia. The stimulus that starts ejaculation is generated in the spinal reflex center, which is controlled through the brain stem by several nuclei of the brain, including the preoptic and paraventricular.

You can buy Priligy (Dapoxetine) at the best price available online from $1.08 for 30 mg, $1.31 for 60 mg pill.

The mechanism of action of Priligy in premature ejaculation is associated with inhibition of the reuptake of serotonin by neurons, followed by an increase in the action of the neurotransmitter on pre- and postsynaptic receptors. The mechanism of ejaculation is regulated mainly by the sympathetic nervous system. Postganglionic sympathetic nerve fibers innervate the seminal vesicles, the vas deferens, the prostate, the urethra and the neck of the bladder, causing their coordinated contraction to achieve ejaculation.

Composition

Dapoxetine + excipients.

Pharmacokinetics

Dapoxetine is rapidly absorbed, and the maximum concentration in the blood plasma (Cmax) is reached 1-2 hours after taking the drug. The intake of fatty food moderately reduces Cmax of dapoxetine (by 10%) and increases by 12% the AUC and the time to reach the maximum concentration in the blood plasma.

However, the degree of absorption of dapoxetine remains unchanged. These changes are not clinically significant. Priligy can be taken regardless of food intake. More than 99% of dapoxetine binds to plasma proteins. The active metabolite, desmethyldapoxetine, binds to plasma proteins by 98.5%. Dapoxetine is rapidly distributed throughout the body with an average equilibrium volume of distribution of 162 liters. Studies suggest that dapoxetine is metabolized by many liver and kidney enzymes, especially CYP2D6, CYP3A4 and flavin-containing monooxygenase (FM01) kidney.

In a clinical study in which the metabolism of 14C-dapoxetine was studied, dapoxetine was actively metabolized after oral administration mainly by N-oxidation, N-demethylation, hydroxylation of the naphtho group, glucuronization and addition of the sulfo group. After oral administration, signs of a pre-systemic metabolism in the liver were found. The main components circulating in the blood plasma were intact dapoxetine and dapoxetine-N-oxide. In studies, it was found that dapoxetine-N-oxide is inactive. In addition, desmethyldapoxetine and didezmethyldapoxetine were detected in an amount of less than 3% of the total number of circulating metabolites of dapoxetine.

The study found that desmethyldapoxetine is comparable in activity to dapoxetine, and didezmethyldapoxetine is about 2 times less active than dapoxetine. The exposure (AUC and Cmax) of unbound desmethyldapoxetine was 50% and 23% of unbound dapoxetine, respectively. Metabolites of dapoxetine are excreted mainly with urine in the form of conjugates. An unchanged active substance in the urine is not detected.

Dapoxetine is rapidly excreted, as evidenced by the low concentration of the substance in the blood plasma (less than 5% of the maximum) 24 hours after the dose. With daily intake of accumulation of matter in the body is minimal. When taken orally, the final elimination half-life is approximately 19 hours. A single dose of dapoxetine in a dose of 60 mg did not reveal a significant difference in pharmacokinetics in healthy older men and men of a younger age.

Indications for use

The treatment of premature ejaculation in men aged 18 to 64 years (reflex enhancement of potency due to prolonged sexual intercourse and increase confidence).

Forms of release

Tablets coated with 30 mg and 60 mg.

Instructions for use and intake chart

For oral administration. The tablet should be swallowed whole, washed down with at least one full glass of water. Priligy can be taken regardless of food intake.

The recommended initial dose for all men is 30 mg; this dose is taken 1-3 hours before the alleged sexual intercourse. With insufficient effect and good tolerability of 30 mg dose, it can be increased to 60 mg. The maximum recommended dose frequency is 1 time every 24 hours.

The doctor who prescribes Priligy for the treatment of premature ejaculation should assess the risk and benefit of using the drug after the first 4 weeks of treatment or after taking 6 doses and should determine the risk-benefit ratio for making a decision about expediency of further treatment with Priligy.

Potential Priligy side effects may include:

Effect
Percentage
36%
27%

Priligy used to treat the following diseases:

Disease
Percentage
  1. John G. Dickens says:
    3.5 rating

    Hello, I would like to briefly share my experience with Priligy. So taken pill, after about 1.5 hours of sex with my partner. So I can only say, min. 3x as before, I could have done even longer. Now to the side effects: Light headache but you forget the sex, easy discomfort – not too bad.

  2. Kevin A. Morris says:
    5.0 rating

    Priligy for Premature Ejaculation

    I have Priligy prescribed by my doctor, since I am usually already came after 2-3 bumps. I had hope for at least 3-5 minutes. Unfortunately, the price at about 10 € per tablet is quite high and you have to wait at least 1 hour until the effect occurs completely. If you eat plenty before or while, the side effects such as dizziness and evil are limited. But if you take the tablet on an empty stomach, it causes very strong dizziness and nausea. The effect of Priligy is coping! Allegedly, the ejaculation is so delayed only by 1 minute (according to independent research), but I can not believe that almost. I’ll go through at least three quarters of an hour (!)! It’s almost frustrating that I just can not come while my girlfriend has already reached orgasm. I honestly can not explain why I’ve been holding out for so long, but it’s just that. I’m really grateful to the drug, a much lower price would be quite nice, but that’s the way it is, if you have a virtual monopoly position.

    Side effects: Nausea; Dizziness
  3. Gary S. Jones says:
    3.5 rating

    The drug has the desired effect and helped to prolong. However, many side effects have occurred with me. These have also passed quickly. Nevertheless, one should first consider whether the relation of price and effect is actually worthwhile?

    Side effects: Nausea
  4. Eric D. Roundtree says:
    3.5 rating

    Priligy for Premature Ejaculation

    Have ordered the drug at a mail order pharmacy. After taking it I had about 1 hour of sex. The pill works amazingly well and I was able to last much longer. However, the downside was that I often woke up at night and my head felt like everything was slowing down. It’s hard to describe, a little dizziness and somehow slow thinking. Unfortunately, this also stopped after getting up. Conclusion I would take it again, but only if I have nothing to do the following day.

    Side effects: Dizziness
  5. Brady M. Peeples says:
    2.5 rating

    Priligy for Premature Ejaculation

    I got the medicine prescribed by my urologist. I have been suffering from premature ejaculation for several years now. Unfortunately, the drug had no positive effects. There were only side effects such as dizziness.

    Side effects: Dizziness
  6. Clinton S. Sparks says:
    3.0 rating

    Priligy for Premature Ejaculation

    the premature ejaculation was a serious problem for me. I was frustrated and nervous because I did my best every time to have normal sex.

    Side effects: Nausea; Dizziness
  7. Paul B. Swearengin says:
    3.0 rating

    Priligy for Premature Ejaculation

    The best experience I had with Super Tadapox i. Tadalafil and Dapoxetine. It seems after Dapoxetine alone there are no side effects, with Super-P Force, I noticed a headache like the hangover. Tadalafil works with virtually no side effects.

    Side effects: No side effects
  8. James E. Crawford says:
    4.0 rating

    Priligy for Premature Ejaculation

    I ordered Priligy online through an Elite pharmacy and can only report positive. After about half an hour we started the sexual intercourse and I was able to last much longer than usual. While I usually came to ejaculation after a minute or two without Priligy, I was able to perform fast and strong stimulation movements with Priligy for several minutes without to have to come. Finally my wife has come before me …. I could then really enjoy coming to orgasm.

    Side effects: No side effects
  9. Larry T. Fortin says:
    4.5 rating

    Priligy for Premature Ejaculation

    Super P-Force is my favorite. If I take it, I can satisfy my girlfriend longer; I am satisfied and she is satisfied too. Super P-Force is our friend. Actually, this is my 3rd girlfriend; I did not know before that there was such a drug, so my ex-girlfriends, after the first night together, did not want to stay with me anymore. It helped me well, could delay the climax to 7 minutes. Today, after one year of use, I do not need it anymore.

    Side effects: No side effects