Prednisone contraindications and warnings


Following is information on contraindications to the use of prednisone in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When can prednisone not be used?

Hypersensitivity to prednisone precludes treatment with this drug.

If the administration of prednisone is considered strictly necessary by the doctor, it can be used at short notice without further restrictions. However, a longer-term use is prohibited at

  • acute viral infections such as cold sores, shingles, polio and chicken pox
  • chronic active hepatitis with positive HBsAg reaction
  • Vaccinations eight weeks prior to and two weeks thereafter
  • Lymph node swelling after tuberculosis vaccination

Only after risk-benefit consideration by the doctor and under his control should be treated with prednisone at

  • Gastrointestinal ulcers and treatment with acid blockers
  • severe bone loss (osteoporosis)
  • Psychoses in Prehistory
  • Internal (systemic) infections with bacteria, fungi and microorganisms (parasites)
  • Green Star (narrow and wide angle glaucoma).
  • severe ulcerative colitis with a risk of breakthrough, in diverticular disease and after bowel bypass surgery (anastomotic surgery)
  • difficult to treat high blood pressure
  • diabetes.


In acute and chronic bacterial infections, in addition to prednisone, a targeted therapy with antibiotics must be made. Prednisone can mask the signs of infection, making it difficult to detect an existing or developing infection.

In tuberculosis in medical history, prednisone use is only possible with adequate tuberculosis protection because of the risk of a reoccurrence of the infection allowed

Prednisone may increase the need for insulin or oral antidiabetics in patients with diabetes.

Prednisone requires regular blood pressure monitoring in patients with severe hypertension. Patients with severe myocardial insufficiency should be carefully monitored by a doctor as there is a risk of worsening the disease.

In elderly patients, the use of the active substance should only be carried out with special benefit / risk consideration, as the risk of bone loss in this patient is high Patient group is elevated.

What should you watch out for during pregnancy and lactation?

During pregnancy, prednisone should be used only after careful consideration of the benefit and risk by the physician, as growth disorders of the uterine can not be excluded. If prednisone is used towards the end of pregnancy, the child may become ill with adrenocortical dysfunction. In this case, the neonate will have to undergo a gradual replacement therapy with prednisone.

Glucocorticoids such as prednisone pass into breast milk and can thus reach the infant. In order to avoid damage to the child, the use of the active substance should take place only after medical consultation. In the best case, the child is weaned from treatment with prednisone.

What should be considered in children?

The use of prednisone in children of growing age should only take place after careful consideration of the benefit and risk by the attending physician, as growth may be impaired.

For the treatment of respiratory diseases in children such as Pseudo-Krupp, the active ingredient is available in the form of suppositories.

Warnings and Precautions

  • Regular medical checks are required during treatment with the drug, especially in patients with severe heart failure.
  • Use of the drug requires adequate potassium intake. The potassium level of the blood should be checked regularly.
  • Skin reactions to allergy testing can be suppressed by treatment with the drug.
  • Prolonged treatment should be stopped slowly.
  • Hypothyroidism and cirrhosis of the liver require special dose adjustment by the doctor.
  • At three-monthly intervals, ophthalmological checks should be performed during treatment with the drug.
  • Immune-compromised children and persons without previous chickenpox or measles infection are to be monitored especially by a doctor.
  • Viral diseases (chickenpox, measles) can be particularly severe during treatment.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.