What side effects can prednisone have?
Below you will find the most important information about possible known side effects of Prednisone.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Prolonged internal use of prednisone is always expected to produce adverse effects to varying degrees. The only exception is the compensation treatment (substitution) of missing endogenous hydrocortisone in adrenal cortical disorder.
Very common side effects:
Bone fragility (osteoporosis), increased appetite, increased drive.
Common side effects:
Disturbance of sugar metabolism, diabetes mellitus in previously seemingly healthy, fat redistribution (Stammfettsucht, bull’s neck, full moon face), increased risk of vascular calcification, increased risk of infection, favoring viral and fungal infections, muscle changes, skin shrinkage, skin – or mucosal bleeding, subcutaneous bleeding, growth inhibition (in children), headache.
Occasional side effects:
“paper skin” with red streaks, steroid acne, skin color changes, eye changes, glaucoma.
Rare side effects:
Inhibited excretion of sodium and fluid, calcium deficiency, potassium deficiency, bone death (high-dose internal use), increased excitability, restlessness, moodiness (euphoria or depression), psychosis, skin inflammation around the mouth , Brain swelling (in children), local body fat deposits, menstrual disorders, overhair, high blood pressure, palpitations, heart stuttering, disturbed heart conduction (AV block).
Isolated side effects:
tendency to epileptic seizures, epileptic seizures so far apparently healthy, pancreatitis, impotence.
Adverse reactions without frequency:
changes in the blood count, premature vascular calcification, gastrointestinal ulcers, gastrointestinal tract breakthroughs, delayed wound healing, vascular blockage.
Side effects without frequency in long-term treatment:
Functional failure of the adrenal cortex, hypersensitivity reactions to allergic shock.
Excessive dose reduction after prolonged prednisone treatment can cause discomfort such as muscle pain and joint pain.
What interactions does prednisone show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
With simultaneous use of NSAIDs from the salicylate subgroup or indomethacin and other non-opioid analgesics is a risk of gastrointestinal ulcers and bleeding may increase. Regular medical checks are required.
The hypoglycemic effect of oral antidiabetics for ingestion and insulin is diminished by prednisone. That’s why blood glucose checks often have to be done. The doctor decides on an individual dose adjustment.
barbiturates, phenytoin and primidone (all antiepileptics) and rifampicin (tuberculosis agent) reduce the effect of prednisone. Therefore a regular check of the treatment success is recommended.
Anticoagulants such as phenprocoumon are attenuated in their effect. Therefore, when taking it at the same time a dose adjustment of the anticoagulant by the attending physician is required.
Estrogen, as used in birth control pills, can potentiate the effects of prednisone. The doctor may need to adjust the dose during treatment.
An additional intraocular pressure increased with concomitant use of prednisone and atropine and other muscarinic receptor antagonist (inhibiting the action of the neurotransmitter substance acetylcholine) is not excluded. Therefore, regular check-ups are recommended.
Prednisone leads to increased potassium excretion. With simultaneous use of dehydrating agents there is an increased potassium excretion. Laxatives can also cause or increase potassium loss. Therefore, regular blood potassium checks are necessary during the treatment. Cardiac glycosides can be strengthened by a potassium deficiency in their effect and cause cardiac arrhythmia. In these patients, therefore, the blood potassium content is very often to be checked by a doctor.
Concomitant use of ACE inhibitors (antihypertensives) may increase the risk of blood cell changes. That’s why the doctor should check the blood count more often.
In patients with malaria, the other hand, are treated with chloroquine, mefloquine or Hydrochloroquin, there is an increased risk of developing muscle and heart muscle diseases. Regular medical check-ups are important in these patients.
Prolonged treatment with prednisone may reduce the effects of the growth hormone somatotropin and the release of the pituitary gland hormone TSH in response to the administration of protirelin (a hypothalamic hormone). The attending physician will decide on a possibly necessary dosage adjustment.
The blood concentration of cyclosporin (immunosuppressive effect) is increased by prednisone, which also increases the risk of epileptic seizures. If patients are being treated with these agents, frequent follow-up examinations are necessary.
Prednisone may cause a reduction in blood levels of anti-worm drugs like praziquantel. The treatment success should be regularly checked by a physician for these diseases.