Prednisolone contraindications and warnings


Following is information on contraindications to the use of prednisolone in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Prednisolone not be used?

Hypersensitivity to prednisolone excludes treatment with this drug in all dosage forms. Special limitations depend on the type and location of application:

Internal therapy (tablets, injections)

An internal therapy with prednisolone is generally without any problems, as long as it is short-term and no other diseases exist , It may only be used in the following conditions if the doctor considers it absolutely necessary and if necessary carries out an additional therapy for infections:

  • acute viral infections (shingles, cold sores, chickenpox, polio, corneal infestation with herpes viruses)
  • chronic active hepatitis with positive HBsAg reaction
  • for eight weeks before and two weeks after vaccination with live vaccines
  • Lymph node swelling after tuberculosis vaccination
  • Internal infestation with fungi or parasites (amoebae or worms)
  • Acute and chronic bacterial infections – special care in the case of a history of tuberculosis (concomitant use of tuberculosis against re-emergence).
  • In addition, in-house treatment with prednisolone should only be performed if absolutely necessary and under close monitoring, and if necessary additional targeted therapy at

    • Gastrointestinal ulcers and treatment with acid blockers
    • severe bone loss (osteoporosis)
    • severe heart failure
    • difficult to treat high blood pressure
    • difficult to control diabetes.
    • mental illnesses such as psychosis or depression in history
    • the nerve disease Myasthenia gravis
    • green star (narrow and wide angle glaucoma)
    • Corneal ulcers and corneal injuries.

    Due to the risk of intestinal breakage, prednisolone should only be used in urgent cases and under appropriate medical supervision at

    • severe ulcerative colitis with a risk of breakthrough
    • in abscesses or other purulent inflammations in the intestine
    • diverticular disease
    • Condition after bowel bypass surgery (anastomotic surgery).

    In elderly patients, the risk of osteoporosis is increased by the internal treatment with prednisolone. Therefore, the application should only be made with the special benefit-risk consideration by the doctor.

    Application on the skin
    Prednisolone must not be used in

    • virus-related skin conditions such as cold sores, shingles or chickenpox
    • Special skin diseases like tuberculosis, syphilis and vaccination reactions
    • acne
    • rosacea-like (perioral) dermatitis (inflammatory skin around the mouth with redness and pilling) and rosacea itself (facial redness with possibly inflammatory or purulent pimples).

    In the case of bacterially infected skin diseases and / or fungal infestations, the active substance may only be used in combination with other medicines that are specifically directed against these diseases.

    Application on the eye
    An application on the eye is prohibited at

    • acute herpes infection and other eye infections caused by viruses
    • Bacterial and fungal eye infections without concomitant antibiotic therapy
    • Injuries and growths on the cornea
    • Green Star (narrow and wide angle glaucoma).

    Diseases that cause thinning of the cornea or the lining of the eyeball may lead to a breakthrough.

    Application as Oral Paste
    The use of prednisolone is prohibited

    • Fungal and tuberculosis-related disorders of the oral mucosa
    • chickenpox and vaccine reactions
    • Wounds that are covered by suture or flap plastic.

    In severe purulent infections, prednisolone must be used to control the infection with appropriate medication.

    Prednisolone may mask the signs of infection, making it difficult to detect an existing or developing infection

    Prednisolone may increase the need for insulin or oral hypoglycaemic agents in patients with diabetes.

    Prednisolone requires regular blood pressure monitoring in patients with severe hypertension. Patients with severe H

    Warnings and Precautions

    • Regular medical checks are required during treatment with the drug, especially in patients with severe heart failure.
    • At three-monthly intervals, ophthalmological checks should be performed during treatment with the drug.
    • Care must be taken during treatment to ensure adequate potassium intake, and the level of potassium in the blood should be checked regularly.
    • Hypothyroidism and cirrhosis of the liver require special dose adjustment by the doctor.
    • Cortisone withdrawal syndromes may occur at the end of treatment with the drug. Therapy discontinuation should therefore only take place at a slowly reduced dose (“creeping”).
    • Viral diseases (chicken pox, measles) can be particularly difficult during treatment. Treatment for HBsAg-positive chronic hepatitis (hepatitis) should be avoided.
    • Immune-compromised children and persons without previous chickenpox or measles infection are to be monitored especially by a doctor.
    • Treatment with the drug can suppress skin reactions to allergy tests.
    • The drug is on the doping list and should not be used in sports or competition.
    • Especially at the beginning of an in-patient treatment with the drug, mood, drive and concentration may change, making driving a car or operating machines dangerous.

    Sometimes medications release allergic reactions.
    If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.