Prednisolone side effects

What side effects can prednisolone have?

Below you will find the most important information about possible known side effects of Prednisolone.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Prolonged internal use (over 14 days) of prednisolone is expected to produce adverse reactions of varying severity from a dose of 7.5 milligrams. The only exception is the compensation treatment (substitution) of missing endogenous hydrocortisone in adrenal cortical disorder.

Common side effects
Short-term treatment (high-dose, as an injection):

Rare side effects
Internal long-term treatment:
Hypersensitivity reactions of the skin such as rash, burning and itching.

Local application to the gums:
general hypersensitivity reactions.

Local application on the skin:
allergic skin reactions.

Use on the anus and rectum:
burning and itching on skin-mucosal transitions, superficial gastric mucosal bleeding.

Very rare side effects and isolated cases
Short-term treatment (high-dose, as an injection):
allergic reactions to shock.

Local application to the gums: allergic shock.

Use on anus or rectum:
Cardiac arrhythmia.

Side effects without indication of frequency
Internal short-term treatment:
Bone mass loss.

Long-term internal treatment: Adrenocortical dysfunction with Cushing’s syndrome (full moon face, obesity of the body trunk), growth retardation (in children), sex hormone disorders (missed menstrual period, over-hairiness, impotence), body salt retention with connective tissue retention, increased potassium excretion, weight gain , Glucose metabolic disorder, onset of diabetes, increased blood cholesterol, elevated blood lipid levels, red skin streaks, tissue wasting, skin vascular puncture, steroid acne, delayed wound healing, skin inflammation localized around the mouth, changes in skin color, hypersensitivity reactions such as rash and itching, muscle atrophy , Muscle weakness, osteoporosis, bone dying (head of the upper arm and thigh bone), depression, irritability, elation, increase in drive, appetite increase, psychosis, faked by an inflammatory swelling Tumor formation in the brain (especially in children), occurrence of existing epilepsy, increased seizure readiness, gastrointestinal ulcers, gastrointestinal bleeding, pancreatitis, hypertension, risk of arteriosclerosis, increased risk of vascular blockage (thrombosis), inflammation of the blood vessels (also as withdrawal syndrome Long-term therapy), moderate increases in white blood cells, red and white blood cell reductions, immune deficiency attenuation, generalized infection, spread of existing infections, allergies, cataracts (cataracts), glaucoma, retinal disease.

Rapid injection of high doses into the vein:
Itching or burning in the perineum area.

Longer local application to the eye:
Intraocular pressure increase with possible formation of glaucoma (sensitive patients), cataract (cataract), eye infections, worsening of infection, infection veiling, corneal rupture (in diseases causing dilution of the cornea or the skin of the eye ).

Local application to the gums:
local hypersensitivity reactions.

Long-term local application on the skin:
dermal degeneration, blood vessel marking, banding, steroid acne, skin inflammation around the mouth, overhair.

Injection into joints and muscles:
severe tissue degradation at the injection site (bone dying, melting of muscle and connective tissue).

Special features:
All glucocorticoids, including prednisolone, can reduce the absorption of iodine into the body and its storage in the thyroid gland. Therefore, during long-term use of the drug, the thyroid levels are to be monitored ärtlich.

Excessive dose reduction after prolonged prednisolone treatment may cause discomfort such as muscle aches and joint pain.

What interactions does prednisolone show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Co-administration of non-steroidal anti-inflammatory drugs from the salicylate subgroup or indomethacin and other non-opioid analgesics may increase the risk of gastrointestinal ulceration and bleeding. With such combination regular medical checks are required.

The hypoglycemic effect of oral antidiabetics for ingestion and insulin is diminished by prednisolone. That’s why blood glucose checks often have to be done. The doctor decides on an individual dose adjustment of the sugar medicines.

Barbiturates, phenytoin and primidone (all antiepileptic drugs) and rifampicin (tuberculosis drugs) reduce the effects of prednisolone. Therefore a regular check of the treatment success is recommended.

Anticoagulants such as phenprocoumon are attenuated in their effect. Therefore, when taking it at the same time a dose adjustment of the anticoagulant by the attending physician is required.

Estrogen, as used in birth control pills, may enhance the effect of prednisolone. The doctor may need to adjust the dose during treatment.

An additional intraocular pressure increase with concomitant internal use of prednisolone and atropine as well as other muscarinic receptor antagonists (inhibit the action of the nerve messenger acetylcholine) is not excluded. Therefore regular medical check-ups are recommended.

Prednisolone leads to increased potassium excretion, which is further enhanced by the simultaneous use of dehydrating agents. Laxatives can also cause or increase potassium loss. Therefore, regular medical checks of the potassium content in the blood are necessary during treatment. Cardiac glycosides can be strengthened by a potassium deficiency in their effect and cause cardiac arrhythmia. In these patients, therefore, the blood potassium content is very often to be checked by a doctor.

Co-administration of hypertensives from the ACE inhibitor drug class may increase the risk of blood cell abnormalities. That’s why the doctor should check the blood count more often.

In patients with malaria treated with chloroquine, hydrochloroquine or mefloquine, prednisolone is associated with an increased risk of muscle and heart muscle disease. Regular medical check-ups are important in these patients.

Long-term administration of prednisolone may reduce the effect of the growth hormone somatotropin and the release of the pituitary gland hormone TSH in response to the administration of protirelin (a hypothalamic hormone). The attending physician will decide on a possibly necessary dosage adjustment.

The blood concentration of cyclosporin (immunosuppressive effect) is increased by prednisolone, which also increases the risk of epileptic seizures. If patients are treated with these agents, frequent follow-up examinations are necessary.

Prednisolone may cause a decrease in blood levels of anti-worm drugs. The treatment success should be regularly checked by a physician for these diseases.

In the case of prednisolone in the eye, it should be noted that intraocular pressure may rise when co-administered with substances such as atropine or other muscarinic receptor antagonists (for example, Parkinson’s disease).

Interaction with local application in the mouth or on the skin does not exist.

Potential Prednisolone side effects may include: