Pravastatin contraindications and warnings

Contraindications

Following is information on contraindications to the use of pravastatin in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should not Pravastatin be used?

Pravastatin should not be used with:

  • Hypersensitivity to the active substance
  • Liver disease or a permanent increase in blood liver enzymes
  • Skeletal muscle disease with muscle fiber destruction or an increase in blood levels suggestive of it.

Furthermore, pravastatin should only be used with medical care and only after a careful risk-benefit assessment at

  • People over 70 years old
  • Alcohol Abuse
  • favorable factors for a muscle disorder such as
    • renal dysfunction
    • thyroid
    • hereditary muscle disorders in personal history or family
    • muscle damaging effects from an earlier ingestion of a fibrate or statin
    • Situations in which increased blood levels of the drug may occur, for example, in Asian patients, liver or kidney dysfunction, or concomitant use of other agents such as ciclosporin (for organ rejection) and some AIDS agents from the HIV-1 protease inhibitor group
    • simultaneous use of fibrates.

Note:
Pravastatin is not recommended for use in a special form of lipid metabolism disorder, hereditary homozygous familial hypercholesterolaemia. No studies have been undertaken with pravastatin for this condition.

What should you watch out for during pregnancy and lactation?

The active substance pravastatin is not intended for use in pregnancy. There are no clinical data on harm to the unborn child. However, it is also conceivable that the cholesterol synthesis of the unborn child would be affected by pravastatin. If pregnancy occurs while taking pravastatin, the medicine should be discontinued immediately.

Pravastatin should not be used during breast-feeding. It is known that pravastatin passes into breast milk. If therapy is absolutely necessary during breastfeeding with pravastatin, it should be weaned beforehand.

What should be considered in children?

The use of pravastatin in children and adolescents is treated differently by manufacturers. Some say that the drug should not be used in children and adolescents under 18 years, others allow the gift from age eight years. It is therefore in doubt the doctor to consult.

Warnings and Precautions

  • During the therapy, the liver values are to be monitored by a doctor. When the blood serum levels are more than threefold, the dose of the drug should be reduced or the treatment stopped altogether.
  • The muscle enzymes in the blood must be monitored by a doctor during treatment. If muscle-specific blood levels (creatine kinase) are increased more than fivefold, therapy should be discontinued.
  • In case of pain, cramps, weakness and particular sensitivity of the musculature, especially if they occur together with fever and general malaise, the doctor must be consulted immediately.
  • In case of difficulty breathing, coughing, exhaustion, weight loss and fever the treatment should be stopped.
  • If a patient already has risk factors for the development of diabetes, the blood sugar must be checked regularly during treatment.
  • If there is persistent muscle weakness despite the end of treatment, this must be reported immediately to the doctor.
  • Dizziness may occur during treatment with the drug.
  • Driving a dizziness during therapy can make driving dangerous.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.