What side effects can pravastatin have?
Below you will find the most important information about possible known side effects of pravastatin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
Muscle cramps; Muscle aches; Joint pain.
Occasional or less common side effects:
dizziness; A headache; Fatigue; Sleep disorders; Insomnia; Blurred vision; Double vision; Heartburn (heartburn and inflammation of the esophagus; stomach disorders (dyspepsia); abdominal pain; nausea and vomiting; flatulence); diarrhea; constipation; urinary problems; nocturnal urination; itching; rash; pustules; alopecia; sexual dysfunction. !!
Rare side effects:
Very rare or isolated side effects:
Jaundice (jaundice); Inflammation of the liver; Liver cell death (fulminant hepatic necrosis); Tendon irritation; Musculoskeletal with or without acute renal failure; dry skin; decreased appetite; Dysgeusia; Hair loss; Lens opacity; Hypersensitivity reactions to pravastatin with symptoms such as skin rashes; joint pain; arthritis; Sensitivity to light; Change in specific blood values (reduction of blood cells, increase of erythrocyte sedimentation rate); Vasculitis; depressive moods (depression); Nerve disease; Hair loss; Erectile dysfunction; Sleep disorders, muscle breakdown due to an autoimmune reaction.
All representatives of the drug group of statins seems to have a harmful effect on the nerves, which is particularly evident in the legs. Numbness, burning sensations or muscle twitching are the signs. For such symptoms, treatment with a statin should be stopped immediately. Diabetics are especially at risk because the doctor frequently associates the described symptoms with nerve damage due to diabetes (diabetic neuropathy) and the causative statin is not discontinued.
During or after treatment, muscle atrophy may very seldom occur due to an autoimmune reaction. Signs of persistent muscle weakness persist despite the end of treatment. Such a muscle weakness must be communicated to the doctor immediately.
Other side effects common to all statins, such as memory loss, sexual dysfunction, depression and damage to the alveoli (interstitial lung disease), may also occur with pravastatin.
Like all statins, pravastatin may increase blood sugar levels and promote the development of blood sugar (diabetes mellitus). Frequency is dependent on the presence or absence of other risk factors, such as pre-existing excess blood sugar, obesity, high blood pressure, and the extent of the lipid metabolism disorder.
What interactions does pravastatin show?
Concomitant use of pravastatin with antiviral drug (immunosuppressants) Ciclosporin quadruples the concentration of pravastatin in the blood. This can cause severe cases of muscle rhabdomyolysis. If the simultaneous administration of the active ingredients is unavoidable, the statin must be dosed weaker by the doctor.
The parallel use of pravastatin and fibrates (fenofibrate, gemfibrozil) or the vitamin nicotinic acid increases the risk of muscle disease and therefore can not be recommended.
Concomitant use of anion exchange resins (cholestyramine and colestipol) results in reduced pravastatin intake, therefore pravastatin should be administered at least four hours after or one hour before ingestion of the anion exchange resins.
Concurrent use of pravastatin and acid-binding agents (antacids) reduces pravastatin levels in the blood by 35 percent. Antacids should therefore be taken at least one hour before taking pravastatin.