Pravastatin is used to lower blood cholesterol (lipid metabolism disorders) when a low-fat, low-cholesterol diet, weight-loss and exercise do not lower the cholesterol level.
What is the purpose of this ingredient?
- Lower blood cholesterol
- Lower blood lipid levels
- Lower elevated blood lipid levels in post-transplant defensive control measures
- Reduce heart attack risk
- Prevent recurrence of heart attacks
- Reduce risk of stroke
This is how Pravastatin works
Below you will learn more about the fields of application and the mode of action of pravastatin.
Please also read the information on the drug groups statins, cholesterol lowering, to which the active ingredient pravastatin belongs.
Application of the active substance pravastatin
Pravastatin is used to lower blood cholesterol (lipid metabolism) disorders when a low-fat and low-cholesterol diet, weight reduction and exercise do not provide adequate cholesterol reduction.
The appropriate amount of active substance may range from an initial dose of 10 milligrams to a maximum dose of 40 milligrams once a day. In order to enhance the cholesterol-lowering effect of pravastatin, the active ingredient may be combined with inhibitors of bile acid resorption (anion exchange resins such as cholestyramine and colestipol). However, the anion exchange resins must be at least four hours before or one hour after taking pravastatin.
Furthermore, pravastatin protects against deposits of lime and blood lipids in the blood vessels and thus prevents arterial circulatory disorders. Especially the coronary vessels are sensitive to such deposits and subsequent inflammation. In patients with such a change in the coronary heart disease (coronary heart disease) may lead to a poor circulation of the heart muscle (myocardial ischemia) with the feeling of chest tightness (angina pectoris) to the heart attack.
There is also an increased risk of circulatory problems in the brain, which can manifest as a stroke in the worst case scenario. Pravastatin may prevent the first onset of stroke or heart attack. However, pravastatin may reduce the likelihood of a heart attack reoccurring after angina or myocardial infarction. Therefore, pravastatin is used in high-risk patients for a heart attack or stroke to reduce the risk. This is done by taking 40 milligrams of pravastatin once a day.
Pravastatin can also be used after organ transplantation to lower blood lipid levels, which are increased by the use of anti-depressant drugs (immunosuppressants). The starting dose is 20 milligrams of pravastatin. The dose can be increased to 40 milligrams of pravastatin with frequent medical attention.
For the following application areas of Pravastatin , in-depth information is available:
Effect of pravastatin
Pravastatin belongs to the drug group of statins. It reduces blood cholesterol levels and prevents arteriosclerosis. Likewise, the risk of heart attack and stroke is reduced by pravastatin.
Pravastatin causes a decrease in “bad” LDL cholesterol. The primary site of attack of the drug is the liver. There it inhibits an enzyme involved in the production of cholesterol. Pravastatin is mostly excreted through the liver into the bile and digestive tract and, to a lesser extent, into the urine via the kidney.
The cholesterol-lowering effect occurs approximately two weeks after the start of therapy. Pravastatin is swallowed as a film-coated tablet. The ingestion takes place with some liquid regardless of the meals.