What side effects can mesalazine have?
Below you will find the most important information about possible known side effects of mesalazine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Rare side effects:
Diarrhea, abdominal pain, bloating, nausea and vomiting, headache, dizziness.
Very rare or isolated side effects:
fever, hypersensitivity reactions, respiratory distress, pancreatitis, heart inflammation, pericarditis, muscle pain, joint pain, changes in the blood count, liver dysfunction, hepatitis, renal dysfunction, itching, hair loss.
In case of complaints such as unexplained bleeding, bruising, hypodermic bleeding, anemia, stubborn fever or sore throat, a blood formation disorder can be the cause. In such cases, treatment with the active substance should be discontinued immediately and a doctor should be consulted.
What interactions does mesalazine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The effect of anticoagulants such as phenprocoumon or warfarin is enhanced by mesalazine. This results in an increased risk of bleeding in the stomach and intestine area.
Co-administration of glucocorticosteroids and mesalazine may cause side effects such as stomach ulcers.
Mesalazine increases the hypoglycemic effect of oral antidiabetics such as the sulfonylureas and derivatives.
Together with mesalazine increases the toxicity of the antitumor and methotrexate metabolite.
Renal function may be impaired by the interaction of mesalazine with the combinations of probenecid + sulfinpyrazone and spironolactone + furosemide.