About Pentasa

3.5 rating based on 20 ratings
Rating: 3.5 Reviews: 20
About Pentasa

Mesalazine is used in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. The aim of the treatment is to heal the inflammation and alleviate the symptoms it causes: pain and diarrhea.

What is the purpose of this ingredient?

  • Inhibit inflammation
  • Relieve pain
  • Improve Diarrhea

This is how Mesalazine works

Below you will learn more about the fields of application and the mode of action of mesalazine.
Please also read the information on the drug groups anti-inflammatory, aminosalicylates, to which the active ingredient mesalazine belongs.

Application of the active substance mesalazine

Mesalazine is used in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. The aim of the treatment is to heal the inflammation and alleviate the symptoms it causes: pain and diarrhea.

Melsalazine can be given either by taking it in the form of tablets or by introducing it into the intestine in the form of suppositories, rectal foam or clysters.

More detailed information is available on the following Mesalazin application areas:

  • chronic inflammatory bowel disease

Mode of action of mesalazine

Patients with inflammatory bowel disease suffer from severe abdominal pain and diarrhea. Typically, the disorders are not uniform. There are periods of intense inflammatory activity and severe discomfort with interim periods in which patients are almost symptom free. In the affected persons strongly increased concentrations of endogenous inflammation-promoting substances such as prostaglandins, leukotrienes and interleukins are to be found in the intestinal mucous membranes.

Like all active substances from the group of aminosalicylates, mesalazine blocks the production of these inflammatory mediators and thus has an anti-inflammatory effect. With the drug, the symptoms can be combated in an acute phase of the disease, but it can also prevent relapses in seizure-free time.

Because mesalazine is not absorbed into the rest of the body, it only works locally in the gut and has few side effects.

Potential Pentasa side effects may include:

Effect
Percentage
No side effects
47%
Nausea
11%
Increase in weight
11%
Diarrhea
11%
Fatigue
8%
Hair loss
8%
Joint pain
8%
Bloody chair
8%

Pentasa used to treat the following diseases:

Disease
Percentage
Ulcerative colitis
75%
Morbus crohn
19%
  3. Fredrick M. Oneil says:
    3.0 rating

    Pentasa for Ulcerative colitis

    Diarrhea and blood in the stool. Constant abdominal pain in the lower abdomen, before and during bowel movements extreme abdominal cramps. Likely intolerance of the drug.
    Side effects: Bloody chair; Diarrhea
  4. Timothy E. Payne says:
    2.5 rating

    Pentasa for Morbus crohn

    An improvement in the Crohns has not really occurred. Since I take Pentasa, my joints are hurting (mainly knees, wrists, ankles).
    Side effects: Joint pain
  5. Ellen F. Thompson says:
    3.5 rating

    Pentasa for Ulcerative colitis

    Take pentasa since my 1st batch, 1 time 2gr granules daily. Have been for some weeks water retention in the legs and joint pain. Since my doctor said that I had to continue taking the medicine after the injection, I did not want to sell it on my own.
    Side effects: Joint pain
  6. Joshua K. Davis says:
    3.0 rating

    Pentasa for Ulcerative colitis

    Significant improvement already within days. No diarrhea, no bloody stool and no abdominal pain in the first days of treatment. Flatulence is, however, inevitable due to the air contained in the inlet (Salofalk). Side effects: -light dizziness -Hair loss -extreme acne despite acne standard
    Side effects: Hair loss
  7. Samantha S. Sutton says:
    4.0 rating

    Pentasa for Morbus crohn

    I have been taking this medication for 5 months now and have gained 6 kg (!) Since I am doing sports and eating healthily. I also felt very tired and exhausted every day and could not concentrate properly anymore. I do not take the medication for a week now and feel well again.
    Side effects: Fatigue; Increase in weight
  8. Gerald R. Beauregard says:
    4.0 rating

    Pentasa for Ulcerative colitis

    I always use Pentasa Xtend 2g if I have a colitis attack. The attending physician thinks I could take the Pentasa constantly. During a push I take 2x2g. Pentasa Xtend, in the resting phase, the dosage should be reduced to 1x2g. Because of the detected side effects, I put the Pentasa but completely off after a boost. Side effects that occur with me are: depression, slackness, tiredness, joint pain.
    Side effects: Joint pain; Fatigue
  9. Bessie R. Kempton says:
    4.5 rating

    Pentasa for Morbus crohn

    Take these medications since 5 years tired tired listless I have mood swings
    Side effects: Fatigue
  10. Timothy M. Fitts says:
    3.0 rating

    Pentasa for Ulcerative colitis

    Blood in the stool. Constant diarrhea. 4-5 times a day at the toilet. I probably will not postpone this Medikamet.
    Side effects: Bloody chair; Diarrhea
  11. Johnathon D. Burgess says:
    4.0 rating

    Pentasa for Ulcerative colitis

    Constant abdominal pain and diarrhea. Sometimes blood in the stool. Inflammation has never been normal in my 2 years of treatment.
    Side effects: Bloody chair; Diarrhea
  12. Harry S. Dillon says:
    3.0 rating

    Pentasa for Ulcerative colitis

    I do a lot of sports, but I still struggle with weight gain (body fat) and I honestly can not explain any other cause
    Side effects: Increase in weight
  15. Gladys T. Lee says:
    2.5 rating

    Pentasa for Ulcerative colitis

    Diarrhea, weakness, nausea, gastritis, severe pain in the right upper abdomen, had to stop the treatment, obviously can not tolerate the drug!
    Side effects: Diarrhea; Nausea
  16. Sally A. Coldwell says:
    5.0 rating

    Pentasa for Ulcerative colitis

    Suffering for 7 years from this inscrutable disease. I started with Claversalzäpfchen. Soon no longer tolerated. Then came Salofalkzäpfchen, that did not work. From the darmaligen general then Salofalkeinläufe get. Initially slightly better, during a spurt and later incompatibility, can not hold, terrible burning as well as the suppositories, increased urge to run to the toilet. Then Clversal came in the form of white granules, three times a day. The dose was insufficient to bring the colitis to a daily level. Soon after, Pentasa Xtend 2g followed three times a day. Soon, improvement was always associated with side effects (increased bowel activity and laxity, as well as nausea and lack of apetite). An attempt was made to reduce the dose to one or two doses per day. Since I have the dose again erhöt and am a gastroenterologist, told him about it. As a result, I was advised not to change anything in the amount of intake without consulting. In addition, I got prescribed Salofalk 1g rectal foam. Most attempts to hold the foam have failed. I could only hold it in a few cases when the thrust was just in a weaker chamfer, but by no means subsided. The relapses are the worst from lunchtime (1-3 times per hour to the toilet) Only when the last grain of Pentasa Xtend is eliminated, the whole calms down. I do not dare then in the evening to take the third dose, but must after getting up to the toilet, which is also the case during the resting phase. I also suffer from a heart disease that is permanently treated with medication. And here comes another problem, during the push that lasts for weeks makes my heart mitlerweile to work properly. Hair loss, poor liver values, not at any price!
    Side effects: Hair loss; Fatigue; Nausea
  17. Romelia G. Barnes says:
    4.0 rating

    Pentasa for Ulcerative colitis

    Treatment with Pentasa alone – no improvement in colitis, slow but steady worsening. Keien side effects. In addition, azathioprine quite fast (few days) stagnation of worsening and then slow but steady improvement of colitis complaints. For side effects mild to very strong nausea (daily), loss of appetite, listlessness, dullness, depression I hope every day that it gets better.
    Side effects: Nausea