Paroxetine side effects

What side effects can paroxetine have?

Below you will find the most important information about possible known side effects of paroxetine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Very common:
nausea, sexual dysfunction.

Appearance, drowsiness, insomnia, agitation, dizziness, tremors, yawning, constipation, diarrhea, dry mouth, sweating, weakness, weight gain.

abnormal bleeding in the skin and mucous membranes, confusion, delusions, unwanted movements, blurred vision, sinoatrial cord tachycardia, transient rise in blood pressure, transient drop in blood pressure, rash, itching, urinary retention.

Blood sodium deficiency (predominantly in elderly patients), exaggerated activity (mania), anxiety, alienation experiences, panic attacks, Zappeligkeit,
seizures, heartbeat slowing, liver enzyme increase in value, blood concentration increase of the hormone prolactin, morbid milk flow , Muscle aches, joint pain.

Very rare:
platelet deficiency, allergic reactions (including hives and Quincke’s edema), adrenocortical restriction, serotonin syndrome (symptoms: agitation, confusion, sweating, delusions, exaggerated reflexes, muscle cramps, chills, palpitations, tremors), Acute glaucoma, gastrointestinal bleeding, liver disease (such as liver inflammation, sometimes associated with jaundice and / or liver failure), skin photosensitivity, penile stiffening, water retention in the arms and legs.

Special features:
Especially at the beginning of the treatment there can be tormenting restlessness and restlessness of the limbs (akathisia), including mouth and face cramps. The symptoms occasionally occurred in patients with underlying movement disorders or with neuroleptics treatment.

If hepatic enzyme levels continue to increase, consideration should be given to stopping treatment with paroxetine.

Headache, nausea, drowsiness, sensory disturbances and anxiety may occur after discontinuation of the drug. These complaints usually resolve within two weeks, but may last for two to three months or more. Cessation of treatment should therefore be limited to weeks or months.

Recent studies have shown that paroxetine’s work on bone augmenting and degrading cells is particularly detrimental to long-term use. This can lead to increased fractures, or the development of osteoporosis.

What interactions does paroxetine show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Concomitant use of MAO inhibitors, lithium and St. John’s wort antidepressants, as well as triptans for migraine, may cause severe reactions, including serotonin syndrome. Likewise, co-administration of cough medicine Dextromethorphan can also lead to a serotonin syndrome. Signs of serotonin syndrome include: increase in heart rate, increase in blood pressure, sweating, “feeling sick”, nausea, diarrhea, headache, rapid breathing, dilation of the pupil, restlessness, delusions, disorders of consciousness and movement, tremors and muscle spasms.

The blood level and thus the effect and side effects of neuroleptics such as thioridazine, pimozide and tri- and tetracyclic antidepressants can be increased by paroxetine intake.

Co-administration with anticoagulant drugs (anticoagulants) and non-steroidal anti-inflammatory drugs, as well as acetylsalicylic acid and other antiplatelet agents, may increase the risk of bleeding.

Paroxetine degradation in the body is accelerated by the antiepileptic drugs carbamazepine, phenobarbital and phenytoin, as well as the tuberculosis drug rifampicin. If necessary, a dose adjustment by the doctor is necessary in combination.

Taking paroxetine daily results in a significant increase in the blood levels of procyclidine (against Parkinson’s disease). If severe side effects occur with Parkinson’s treatment with this drug, the doctor should reduce the procyclidine dose.

If breast cancer patients are treated with the cytostatic tamoxifen, paroxetine may limit its effectiveness. The active substance inhibits the enzyme for the conversion of tamoxifen into its active form endoxifen. As a result of this interaction, the mortality rate in the affected patient group increases. In order not to jeopardize the success of tamoxifen treatment, the doctor should choose venlafaxine as an antidepressant because it does not interfere with the enzyme.

Potential Paroxetine side effects may include: