What side effects can rabeprazole have?
Below you will find the most important information about possible known side effects of rabeprazole.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
headache; Diarrhea; Nausea; Stomach pain; Constipation; bloating; Vomiting (nausea and vomiting); Back pain; influenza-like symptoms; Insomnia; Infections.
Occasional side effects:
rash; Redness; Dry mouth; Airway inflammation; Fatigue; Nervousness; Sleepiness; Indigestion; Muscle aches; joint pain; urinary tract infections; Fever; Liver enzymes elevations; Leg cramps.
Rare side effects:
liver inflammation; Kidney infections; increased sweating; Weight gain; Depression; loss of appetite; allergies; blurred vision; Blood disorders; Gastritis.
Very rare side effects:
large redness of the skin; extensive rashes accompanied by fever.
An acute kidney inflammation (interstitial nephritis) caused by rabeprazole is rare. However, because the drug is prescribed very often, the risk is nevertheless significant. This side effect is particularly dangerous, as its symptoms are similar to those that led to the administration of rabeprazole: nausea, vomiting, general malaise. If these symptoms continue to occur during the treatment with rabeprazole, or if the physician detects increased levels of inflammation of unclear origin in the blood, this side effect must be considered. Permanent kidney damage can only be avoided if rabeprazole is stopped in good time and if the kidney is detected and treated early.
All proton pump inhibitors, especially when used at high doses and for more than one year, may increase the risk of hip, wrist, and columnar fractures. This is especially true in older patients or in the presence of other known risk factors (for example, the use of glucocorticosteroids). Therefore, in particular, ostoporosis patients receiving rabeprazole must be carefully observed by the physician for their bone density.
What interactions does rabeprazole show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The change in acidity in the stomach may affect the uptake of other drugs into the bloodstream. For example, the intake of ketoconazole and itraconazole (active substances against fungal diseases) is impaired.
Rabeprazole may increase the concentration of digoxin (cardiac glycoside) in the blood, so its dosage may need to be reduced by the doctor.
Because all agents in the proton pump inhibitor group hinder the efficacy of clopidogrel (for blood thinning), they should not be used with this substance. However, if this is unavoidable, pantoprazole is preferable to all other proton pump inhibitors.