The following provides information on contraindications to the use of olanzapine in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When should Olanzapine not be used?
Olanzapine should not be used in hypersensitivity to olanzapine and chemically related neuroleptics, and in people with high intraocular pressure (glaucoma).
Injecting the drug into the muscle (intramuscular use) is prohibited at
- strong heart muscle weakness
- Disease-causing (unstable) angina pectoris
- Disorders of the excitation in the heart
- Condition after a heart attack or heart surgery
- severe hypertension
- severely slowed heartbeat (bradycardia).
All patients receiving olanzapine intramuscularly should be carefully monitored for heart rate and respiratory rate, blood pressure and level of consciousness.
The doctor has to take extra care with olanzapine in
- Patients with diabetes mellitus
- Disorders of blood formation in the bone marrow or changes in the blood picture
- liver dysfunction
- Tendency to seizure
- benign prostate enlargement (due to the risk of urinary retention)
- previous intestinal paralysis (ileus).
Note: Older people with Parkinson’s disease, dementia and psychosis are at an increased risk of stroke when given olanzapine therapy. Such patients must be monitored carefully and their treatment should only be done with careful consideration of the risks and benefits of the physician.
What should you watch out for during pregnancy and lactation?
The active substance should not be used during pregnancy and lactation because the safety of the use for mother and child has not been established. Women of childbearing potential should take contraceptive measures during therapy.
Mothers who take the drug in the last trimester of pregnancy endanger their newborns by causing side effects such as movement disorders and withdrawal symptoms. These can be in excitement, muscle tension or flaccidity, tremor, drowsiness, dyspnoea or disturbances in food intake. Such newborns must be carefully monitored by a doctor.
What should be considered in children?
Since there is insufficient experience in pediatric use, it is not recommended to use olanzapine in people under 18 years of age.
Warnings and Precautions
- Regular checks on blood counts, blood pressure and liver function are necessary during treatment.
- Patients with diabetes and risk factors for the development of diabetes must be specially monitored by the doctor during treatment with the drug.
- The cessation of treatment with the drug should be gradual (“creeping”).
- The drug is not suitable for treating psychosis caused by dementia.
- If flu-like symptoms, rash on the face and on the body, high fever and lymphadenopathy occur, seek medical attention immediately.
- Responsiveness, ability to drive and use machinery may be impaired.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.