What side effects can Olanzapine have?
Below you will find the most important information about possible, known side effects of Olanzapine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
disorders of exercise control, weight gain, drowsiness, increase in blood sugar, lipid metabolism disorders, increased release of prolactin (hormone that stimulates breast milk production).
Common side effects: constipation, dry mouth, difficulty urinating (micturition disorders), dizziness, inability to sit still (akathisia), involuntary movements such as twitching or tics (dyskinesia), blood pressure and pulse fluctuations, accelerated or decelerated heartbeat , Falling blood pressure from lying down, short-term unconsciousness, disorders of liver function, nausea and vomiting, loss of appetite, hypothyroidism.
Uncommon side effects:
Water retention in the tissues (edema), increased photosensitivity, blood cell abnormalities in the bone marrow, changes in the blood count.
Rare side effects:
Hypersensitivity reactions (skin rashes, swelling due to fluid leakage from blood vessels (angioedema), itching).
Very rare side effects:
liver inflammation, jaundice, inflammation of the pancreas, severe restlessness and confusion, hair loss, cardiac arrhythmia, myocarditis, development or marked worsening of diabetes mellitus.
Severe clotting disorders, seizures, diabetic coma due to high blood sugar levels, decomposition of muscle tissue (rhabdomyolysis), persistent, painful erections (priapism).
Side effects of unknown frequency:
Drug hypersensitivity (DRESS syndrome).
An increased concentration of the hormone prolactin can cause a feeling of tightness in the breast, breast enlargement or milk secretion.
If muscle stiffness, high fever, circulatory collapse and consciousness cloudiness occur, all signs of a neuroleptic malignant syndrome, the treatment must be stopped.
In the elderly and those with dementia, there are frequent observations of walking difficulties (associated with an increased risk of falling) during therapy, an increase in body temperature, redness, pneumonia, urinary incontinence, listlessness, delusions and worsening of Parkinson’s disease (increase in tremors or muscle stiffness).
Sweating, insomnia, tremors, anxiety disorders or severe nausea are common causes of the substance being suddenly discontinued.
If it comes to flu-like discomfort and rash on the face, which then spreads across the body, high fever and lymphadenopathy, this may be the so-called DRESS syndrome. In such cases patients must consult a doctor as soon as possible
What interactions does Olanzapine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The consumption of alcohol increases the dampening effect of Olanzapine.
Some tricyclic and tetracyclic antidepressants, such as fluvoxamine, inhibit the breakdown of olanzapine, which may increase its effects and increase the risk of cardiac arrhythmias.
Smoking and treatment with the active ingredient carbamazepine shorten the duration of action of Olanzapine.
The use of activated carbon reduces the uptake of olanzapine from the intestine.
The active ingredient reduces the efficacy of dopamine receptor agonists for the treatment of Parkinson’s disease.
Concomitant therapy with other neuroleptics or anticholinergics may increase side effects such as dry mouth, constipation and palpitations and may also cause narrowing of the pupils and vision problems. MAO inhibitors can also increase these and other side effects of olanzapine.
Opioid analgesics, beta-blockers or antiarrhythmic drugs may be potentiated by olanzapine in their effect.
There is an increased risk of white blood cell depletion (leukopenia) when co-administered with valproic acid (used to treat epilepsy).