What side effects can Ofloxacin have?
Below you will find the most important information about possible known side effects of Ofloxacin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
upset stomach, abdominal pain, loss of appetite, nausea and vomiting, diarrhea (possibly bloody).
Uncommon side effects:
headache, dizziness, insomnia, restlessness, confusion, palpitations, lower blood pressure, rash, itching.
Rare side effects:
Liver elevation in the blood, liver dysfunction, increase in bilirubin levels in the blood, drowsiness, tremors, gait insecurity, movement control disorders, seizures (epilepsy), blurred vision (double vision, color vision, blurred vision), taste disorders, odor disorders (up to the loss of taste or smell), deafness, tinnitus, nightmares, psychosis (agitation, anxiety, depression, delusions).
Very rare side effects:
jaundice (due to biliary congestion), hepatitis, liver damage, hearing loss, circulatory collapse, fainting, obstruction of consciousness, anemia, reduction in white blood cells, decrease in granulocytes (subgroup of white blood cells), reduction of platelets, complete Blood cell depletion, bone marrow destruction (bone marrow depression), red blood cell burst (hemolytic anemia), renal dysfunction, blood creatinine elevation, nephritis, renal failure, skin pustules, skin blisters (bloody), skin rash (nodular with crusts), vasculitis, erythema exudativum multiforme (garland-shaped red skin rash), skin symptoms resembling scalded skin (Lyll’s syndrome), Stevens-Johnson syndrome (blistered rash with high fever), skin damage, inflammation of the mucous membranes (nodular rash on exposed skin), nail discoloration, nail detachment, sunburn ä similar symptoms), allergic reaction (burning eyes, coughing, runny nose, increase in blood pressure, facial swelling, dyspnea, allergic shock, fever, sweating), tendinitis, tendon rupture, myalgia, muscle weakness, muscle rash (rhabdomyolysis), joint pain, tendon pain, increased blood sugar, hypoglycemic reduction. !! !!
Cases of porphyria (a condition in which the formation of the red blood pigment hemoglobin is disturbed) have occurred during treatment.
Eye treatment – Common side effects:
Eye irritation, mild eye pain.
Hypersensitivity (including allergic diseases of the eyes), dizziness, corneal inflammation, conjunctivitis, blurred vision, photophobia, eye swelling, foreign body sensation in the eye, increased tearing, dry eye, eye pain, itching of the eyes, itching of the eyelids, Eye redness, nausea, swelling around the eye socket, facial swelling.
What interactions does Ofloxacin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
If you take gastric acid (mineral antacids) or sucralfate (mucosal protective gastric acid), the effect of ofloxacin may be reduced. The same applies to aluminum, iron, magnesium and zinc. Therefore, Ofloxacin must be taken about two hours before such preparations.
Concomitant use of other anticonvulsant drugs may result in seizures. These medicines include, for example, non-steroidal anti-inflammatory drugs (cortisone-free anti-inflammatory analgesics) such as fenbufen or theophylline (used to dilate the bronchi, inter alia in asthma).
Especially with high-dose treatment care must be taken to ensure that ofloxacin and other renal drugs such as probenecid (uric acid excretion promoting agent), cimetidine (reduces acid production in the stomach), furosemide (dehydrating effect) and methotrexate (cytostatic, anticrow-inhibiting substance) mutually in their elimination. This can lead to increased blood concentrations of these drugs. Furthermore, the risk of side effects increases.
Ofloxacin may potentiate the effects of coumarin derivatives (blood coagulation inhibitors). Therefore, patients who are being treated with these medicines at the same time must be carefully monitored by a doctor.
In addition, ofloxacin may cause a small increase in the blood concentration of glibenclamide (hypoglycemic effect). So it is more likely to hypoglycaemia of the blood, Therefore, in such cases, a more accurate blood glucose monitoring is recommended.
Furthermore, laboratory tests such as opiate (strong analgesics) or porphyrin determinations (to detect a specific blood formation disorder) in the urine during an ofloxacin treatment may be false-positive.
External use of ofloxacin in eye drops or ointments does not interfere with other medications.