What side effects can amlodipine have?
Below you will find the most important information about possible known side effects of amlodipine.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the side effects in nature and frequency (eg, tablet, spray, ointment) may be different depending on the dosage form of a drug.
Common side effects:
Water retention in tissues (edema) such as ankle swelling, lower leg swelling, water retention especially in the arms and legs (peripheral edema).
Uncommon side effects:
hair loss, redness and heat sensation (reddening), headaches, dizziness, fatigue, drowsiness, palpitations (palpitations) and palpitations (tachycardia), angina pectoris attacks, changes in body weight (increase or decrease) , Blood pressure fluctuations with sudden drop in blood pressure, skin rashes, small skin bleeding (purpura), skin discoloration.
Rare side effects:
Joint pain, back pain, muscle cramps, muscle pain, weakness, nerve pain especially in the arms and legs (peripheral neuropathy), nervous abnormalities (paresthesia), mood swings, blurred vision, nausea, gastrointestinal disorders such as abdominal pain , Bloating, indigestion, diarrhea, pancreatitis, dry mouth, gum proliferation, increased sweating, circulatory disorders, increase in chest tightness, circulatory problems, fainting, increased blood sugar (hyperglycemia), blood disorders such as lack of white blood cells, lack of red blood cells, lack of platelets or Absence of granulocytes, erectile dysfunction, enlargement of the mammary glands, urinary problems, nocturnal urgency, liver dysfunction with an increase in certain liver enzymes, gastritis, vascular inflammation, respiratory distress , changed taste, tinnitus.
Very rare side effects:
Allergic skin reactions (such as redness, itching, hives, blotchy-blistered rashes or redness (erythema), pain and increased skin temperature the arms and legs), light-induced skin reactions, inflammation of the liver with or without jaundice, drainage disorders bile, blood sugar levels in diabetes mellitus.
Chance of side effects.
tremors, slight and transient changes in visual performance, hypotension, arrhythmia, development of heart muscle disease or aggravation of existing heart failure to heart attacks, allergic shock, renal dysfunction in the present kidney failure
In long-term treatment, it can in rare cases in older patients to breast growth (gynecomastia) come.
What interactions does amlodipine show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
The hypotensive effect of amlodipine may be enhanced by other antihypertensives and tricyclic antidepressants. When combined with nitrates, the effects on blood pressure and heart rate may increase. Concurrent use of amlodipine and beta-blockers requires careful medical monitoring of patients, as the hypotensive effects may increase. Beta-blockers can worsen myocardial insufficiency, so patients with heart failure should be monitored with extra care by the doctor during concomitant treatment with amlodipine. The same applies to the administration of antiarrhythmic drugs such as amiodarone and quinidine, since amlodipine may also reduce cardiac output in addition to the antiarrhythmic drugs.
When taken with amlodipine and sildenafil (an erectile dysfunction remedy), each drug has its own antihypertensive effect on its own.
Amlodipine is broken down in the body by an enzyme whose activity can be affected by many other agents. Concurrent administration therefore requires careful medical supervision.
Substances that inhibit this enzyme may cause amlodipine to degrade more slowly when administered concomitantly and then be more potent and longer. These substances include: the fungicides ketoconazole and itraconazole, the antihypertensive drug diltiazem, HIV-1 protease inhibitors (for AIDS), the macrolide antibiotics clarithromycin, erythromycin and telithromycin and the antidepressant nefazodone.
Likewise, agents that promote the activity of the enzyme may attenuate the amlodipine effect. This is the case with the tuberculosis drugs rifampicin and rifabutin, the AIDS drug nevirapine, St. John’s wort (for depression), the glucocorticoid dexamethasone and the antiepileptic drugs phenobarbital, phenytoin and carbamazepine.