What side effects can Norfloxacin have?
Below you will find the most important information about possible known side effects of norfloxacin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
nausea, diarrhea, rash.
Occasional side effects:
feeling of weakness, headache, dizziness, tiredness, insomnia, agitation, confusion, vomiting, indigestion, flatulence, abdominal pain, loss of appetite, joint pain, itching, hives, taste disorders (bitter), odor disorders, changes in the blood picture (reduction of the white blood cells), elevation of eosinophilic cells (certain subgroup of white blood cells), joint pain, increase in liver blood, jaundice (due to biliary congestion), increase of renal value in the blood, eye burning, eye vasculitis.
Rare side effects: allergic reaction (such as facial swelling, drop in blood pressure, skin rash, circulatory failure, drug fever), changes in blood count, anemia, increase in white blood cells, decrease in granulocytes (certain subgroup of white blood cells), reduction of platelets or increase in blood cell counts Platelets, changes in blood clotting, muscle pain, joint swelling, water retention in the legs, hallucinations, sweating, sensory disturbances (in arms and legs), anxiety, nightmares, depression, tremors, seizures, tachycardia, migraine, fainting, hot flash, photosensitization (nodular rash on exposed Skin disorders), ear noises, hearing loss (temporary), visual disturbances (double vision, color vision), loss of taste, inflammation of the kidneys, impaired renal function, increased blood sugar, kidney stone formation, urinary bleeding, pancreatitis, sensory disorders in arms and Legs with paralysis (Guillain Barre syndrome), tearing.
Very rare side effects:
red blood cell destruction, myasthenia gravis (aggravation of muscle weakness), gait insecurity, diarrhea, liver cell damage, liver failure, increased intracranial pressure, psychosis (even self-injury), blood count changes (complete blood cell loss), tendinitis, Tendonitis, tendon rupture, skin bleeding, bloody skin (bloody), rash (nodular with crusts), inflammation of the vein, erythema exudativum multiforme (garland-like reddening), skin damage as in scalded skin (Lyll’s syndrome), bladder rash with high fever (Stevens-Johnson) syndrome).
Side effects without frequency:
Arterial obstruction (especially in the lungs), shortness of breath, water in the lungs, nosebleeds, blood spitting, hiccups, vaginitis, inflammation of the external genitalia (in women).
Side effects without indication of the frequency on the eye:
Light irritation, itching, foreign body feeling, Lidrandverkrustungen, Borken, coverings, Augenrötung, eye swelling, corneal discoloration, eyelid swelling, tears, corneal deposits, changes of the cornea, Sehverschlechterung.
In case of prolonged applications, infections with yeasts (such as oral thrush) can occur. It is also possible that more bacteria settle at the infection site, which are resistant to norfloxacin. There they can trigger another (second) infection. This is then called Superinfection.
Norfloxacin may cause myasthenia gravis (muscle weakness) to break out (possibly hitherto unknown). This can lead to life-threatening relaxation of the respiratory muscles. If norfloxacin causes air distress, a doctor should be called immediately.
Like all gyrase inhibitors, norfloxacin increases the photosensitivity of the skin. During the treatment, longer and stronger sunshine should be avoided. Likewise, the use of solariums should be avoided during this time. If, nevertheless, a hypersensitivity reaction occurs, the treatment must be stopped.
Elderly patients and patients who are being treated with glucocorticoids (“cortisone”) are particularly affected by tendon tears. Therefore, at the first sign of pain or inflammation therapy with norfloxacin should be discontinued immediately.
Long-term treatment may result in urinary crystal formation. As a precaution, care should be taken to consume enough liquid to prevent crystal formation.
The occurrence of severe and persistent diarrhea during or after treatment with norfloxacin may be an indication of the occurrence of very sel
What interactions does Norfloxacin show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Concurrent use of xanthine derivatives such as theophylline (used in asthma, among others) or caffeine-containing substances increases their concentration in the blood. The effect can thus be strengthened and more side effects can occur.
If norfloxacin is co-administered with mineral acid-binding agents (antacids), iron preparations, zinc preparations, buffered didanosine preparations (for HIV therapy) or multivitamin preparations, its uptake into the body is inhibited. Also, aluminum, calcium, magnesium or sucralfate (used in the treatment of gastric ulcers) may reduce the absorption of norfloxacin into the body. The interval between intake of the individual active ingredients should therefore be at least six hours.
Ciclosporin therapy (used to prevent organ transplant rejection and autoimmune disease) may increase ciclosporin concentrations and increase kidney damage.
The non-steroidal anti-inflammatory drug (cortisone-free analgesic) Fenbufen, in combination with the use of high doses of norfloxacin, leads to an increased incidence of seizures.
Glibenclamide (hypoglycemic) with norfloxacin may cause severe blood sugar. These patients need regular medical attention.
The effect of anticoagulants, such as warfarin, is enhanced during norfloxacin therapy. There may be more bleeding and the bleeding time is prolonged.
Probenecid, an anti-gout agent, increases norfloxacin levels in the blood. An individual dose adjustment by the attending physician may eventually become necessary.
Co-administration with the antibiotic nitrofurantoin will result in a decreased effect. In this case, the treatment success should be checked by the doctor at short intervals.
In rare cases, antibiotic therapy such as norfloxacin can lead to diarrhea. This may jeopardize the safety of the contraceptive effect of the pill, which is why it is advisable to use additional non-hormonal contraceptive measures.