About Nolvadex

3.5 rating based on 8 ratings
Rating: 3.5 Reviews: 8
About Nolvadex

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

What is the purpose of this ingredient?

  • Prevent recurrence of mammary cancers
  • Inhibit the development of secondary tumors
  • Destroy mammary cancer cells and their secondary tumors

This is how Tamoxifen works

Below you will learn more about the fields of application and the mode of action of tamoxifen.
Please also read the information on the drug classes antiestrogens, cytostatics, to which the active ingredient tamoxifen belongs.

Application of the active ingredient Tamoxifen

Tamoxifen is used for follow-up treatment after initial treatment of breast cancer. Tamoxifen is also used to treat daughter ulcers in a breast cancer tumor.

In addition, tamoxifen has been shown to be effective in preventing breast cancer in high-risk patients in a four-year clinical trial (National Surgical Adjuvant Breast and Bowel Study).

For the following application areas of Tamoxifen , in-depth information is available:

  • breast cancer

Effect of Tamoxifen

Some cancers are promoted in their formation and growth by hormones. This is, for example, the case of breast cancer, whose development and spread is dependent on the female sex hormone estrogen. The estrogen attaches to special hormone receptors on the cancer cells and stimulates them to grow.

Tamoxifen belongs to the drug class of antiestrogens and typically blocks the binding of estrogen to the hormone receptor of cancer cells. Due to the lack of growth signal by the hormone there is a decrease in cell proliferation. In the case of metastatic breast cancer, treatment with tamoxifen causes complete or partial regression in about 30% of cases, especially of the secondary tumors in the soft tissues and bones. The probability of recurrence is even around 50 to 60 percent if the presence of estrogen receptors in the tumor tissue has been proven.

In early-stage breast cancer, prolonged non-relapse and survival time can be achieved by tamoxifen therapy after surgery.

Tamoxifen itself does not inhibit the growth of cancer cells. The active substance is converted into the active form endoxifen after absorption into the body in the liver by the enzyme CYP2D6.

Potential Nolvadex side effects may include:



Nolvadex used to treat the following diseases:


  1. Melissa E. Santana says:
    3.0 rating

    Nolvadex for Breast cancer

    Weight loss in the first months, with more calories every day, I got it under control. After 2 1/2 years, cramps in the legs occurred at night.

  2. Allison C. Marsh says:
    4.5 rating

    Nolvadex for Breast cancer

    Corneal changes such as strong differences in thickness of the Hh, crystalline deposits

  3. Margarita G. Williams says:
    4.0 rating

    Nolvadex for Breast cancer

    After almost a year, severe side effects now occur. Am after a year Nolvadex Zoladex – stiff in the joints and back. Have strong back pain, especially when lying or bending over. My tendons hurt and shorten, especially the Achilles tendon hurts strong. I can not walk as I did a year ago. Furthermore, I have ongoing eye infections and I am steadily gaining weight although I am already very careful.

    Side effects: Increase in weight
  4. James I. Romero says:
    2.5 rating

    Nolvadex for Breast cancer

    Back pain, fatigue, Achilles tendonitis, eye inflammation Joint pain

    Side effects: Joint pain; Fatigue
  5. Chastity D. Berry says:
    2.0 rating

    Nolvadex for Breast cancer

    Even before the operation, great tiredness, need of sleep (12-14h) after surgery, at present 10-12 hours, can hardly charge battery, weight gain 5kg, joint pain (shoulders), headache, mood swings

  6. Mildred P. Valenzuela says:
    4.0 rating

    Nolvadex for Breast cancer

    Unfortunately, I can not quite tell the side effects, but heat shots are very strong, sometimes I’m really wet, 10 kg weight gain and in the shackles or the arch tendon often severe pain. The joint pain is stronger 2 weeks after the Zometa infusion. Sometimes falling asleep.

  7. Gail J. Clemens says:
    4.0 rating

    Nolvadex for Breast cancer

    What worries me are the hot flashes. I sweat so much that one might think I came out of the shower !! I also have sleep problems or can fall asleep very badly. But I can live with that. If this reduces the risk of getting breast cancer again, I am happy to accept this because otherwise I am doing very well, whatever I wish you to do.

    Side effects: Hot flashes
  8. Debra J. Chute says:
    4.0 rating

    Nolvadex for Breast cancer

    I am in my mid 30s, the side effects increase from year to year: hot flashes at least 20 times a day, circulatory problems, depression, insomnia, tiredness, lack of motivation, lack of concentration, hair loss, …. But thank goodness, nothing has increased. I will still take the medication to avoid relapse.

    Side effects: Fatigue; Hot flashes