What side effects can Esomeprazole have?
Below you will find the most important information about possible known side effects of esomeprazole.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Common side effects:
headache; Stomach pain; Diarrhea; Constipation; bloating; Nausea and vomiting.
Occasional side effects:
dermatitis; Skin rash; Itching; Hives; Dry mouth; Water retention in arms and legs; Insomnia; Dizziness; nervous sensations, tiredness; Liver enzyme appreciation.
Rare side effects:
white blood cell deficiency, platelet deficiency, hypersensitivity reactions (fever, facial swelling, allergic reaction, allergic shock); Blood sodium deficiency; Excitement; Confusion; Depressions; Changes in taste, blurred vision; Incoordination; hearing impairment; bronchospasm; Stomatitis; Yeast infection in the digestive tract; Liver inflammation (with and without jaundice); Hair loss; Light hypersensitivity; joint pain; Muscle aches; Malaise; Welding flux propagation.
Very rare side effects:
granulocyte deficiency; general blood cell deficiency; Aggression, delusions; Liver failure, liver-related brain dysfunction (in patients with pre-existing liver disease); severe skin reactions (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis); Muscle weakness; Nephritis (interstitial nephritis); Breast swelling (gynecomastia).
The following side effects have so far been observed only in omeprazole, the esomeprazole-containing enantiomeric mixture. However, you may also experience esomeprazole: fatigue; Insomnia; Confusion; Excitement; Depressions; Delusions; Enlargements of the male mammary gland (gynecomastia); Oral mucositis; Fungal infections; Blood disorders; Hepatic dysfunction; Renal dysfunction; joint pain; Muscle weakness; Sensitivity to light; Hair loss; increased sweating; low sodium level; Malaise.
Acute kidney inflammation (interstitial nephritis) caused by esomeprazole is rare. However, because the drug is prescribed very often, the risk is nevertheless significant. This side effect is particularly dangerous because its symptoms are similar to those that led to the administration of esomeprazole: nausea and vomiting, general malaise. If these symptoms continue to occur during esomeprazole treatment, or if the physician detects increased levels of inflammation in the blood of uncertain cause, this side effect should be considered. Permanent kidney damage can only be avoided if the therapy with esomeprazole is stopped in good time and if the kidney is detected and treated early.
All proton pump inhibitors, especially when used at high doses and for more than one year, may increase the risk of hip, wrist, and columnar fractures. This is especially true in older patients or in the presence of other known risk factors (for example, the use of glucocorticosteroids). Therefore, in particular, ostoporosis patients receiving esomeprazole must be carefully observed by the physician for their bone density.
Patients receiving proton pump inhibitors such as esomeprazole for longer periods of time (more than three months) are at an increased risk of magnesium deficiency. Cramps, dizziness and delirium can be the consequences. But they get better after replacing the mineral.
By lowering the level of acidity in the stomach, germs can better survive. Therefore, patients have a slightly increased risk of getting gastrointestinal infections with the pathogens Campylobacter or Salmonella.
When the drug is injected, a high level of dosing often causes a skin reaction at the point of use.
What interactions does esomeprazole show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
Altering the acidity (pH) in the stomach can affect the uptake of other drugs into the bloodstream. For example, the intake of ketoconazole and itraconazole (active substances against fungal diseases) is impaired. Esomeprazole also reduces the blood concentration of the AIDS drugs atazanavir and nelfinavir so much that their effects become unsafe. A simultaneous application should therefore be omitted.
Esomeprazole increases the levels of diazepam (sedatives), citalopram, imipramine and clomipramine (all antidepressants) and phenytoin (antiepileptic) when taken concurrently. The reason for this is the predominant use of the same degrading enzyme by esomeprazole.
Conversely, the antibiotic clarithromycin can increase the amount of esomeprazole available in the body by inhibiting the breakdown of esomeprazole in the body.
The combination of esomeprazole with the anticoagulant agent warfarin requires the medical control of coagulation values.
Because all agents in the proton pump inhibitor group hinder the efficacy of clopidogrel (for blood thinning), they should not be used with this substance. However, if this is unavoidable, pantoprazole is preferable to all other proton pump inhibitors.