Naproxen side effects

What side effects can naproxen have?

Below you will find the most important information about possible known side effects of naproxen.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Very common side effects:
nausea and vomiting, diarrhea, slight gastrointestinal bleeding, heartburn, stomach pain, bloating, constipation.

Common side effects:
Gastric ulcers, dyspepsia, flatulence, abdominal cramps, loss of appetite, headache, arousal, irritability, fatigue, drowsiness, dizziness, liver enzyme elevations, intestinal ulcers, gastrointestinal bleeding, water retention in tissue, hematopoietic disorders.

Occasional side effects:
Inflammations of the mouth (stomatitis), inflammation of the tongue, esophageal injuries, gastrointestinal ulcers, blood stools, pelvic pain, intestinal inflammation, photosensitivity, hair loss, asthma attacks, pneumonia, acute renal failure, kidney damage.

Rare side effects:
Skin hypersensitivity reactions, rashes, headache, fatigue, dizziness, blurred vision, hearing impairment, liver dysfunction, increased levels of potassium in the blood (hyperkalaemia), kidney dysfunction.

Very rare side effects:
Severe skin reactions (erythema multiforme, Stevens-Johnson syndrome and Lyell’s syndrome), bowel obstruction, kidney failure, worsening of inflammation, liver damage, gout attacks, kidney failure, bloody vomiting, blood stools, bloody diarrhea, anemia (Anemia), blood cell loss, severe hypersensitivity reactions (such as facial swelling, tongue swelling and laryngeal swelling, dyspnoea, rapid heartbeat, severe circulatory disorders to life-threatening shock).

Special features:
Hypersensitivity to the active ingredient can lead to skin rashes, spasmodic constrictions of the bronchi (bronchospasm) and drop in blood pressure until shock.

Asthma attacks can also occur in people who otherwise do not have asthma. Particularly high is the risk of atopic dermatitis and hay fever patients.

An injection into the muscle can cause a burning sensation at the injection site. In case of incorrect injection, sterile abscesses, so-called fatty tissue necroses, can develop.

Elderly patients are more likely to have adverse effects, especially bleeding and breakthroughs in the digestive tract, even with fatal outcome.

Side effects can be reduced by using the lowest possible effective dose of naproxen for as short a period as possible. The use of the drug may be associated with a slightly increased risk of heart attack or stroke. This risk increases with high doses and longer lasting treatment. The recommended dose or duration of treatment should not be exceeded.

What interactions does naproxen show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Concomitant use of naproxen and digoxin, lithium, methotrexate or phenytoin increases the concentration of these drugs in the blood. It can lead to poisoning.

The concomitant use of anti-diabetic medicines (oral hypoglycaemic agents) increases their blood sugar-lowering effect. It is therefore recommended to have a doctor check blood sugar levels. For diabetics, the dose of the antidiabetics may need to be adjusted by the doctor.

The simultaneous intake of potassium-sparing dehydrating agents (diuretics) increases the risk of an excessively high potassium concentration in the blood.

Antihypertensive agents, diuretics and sulfinpyrazone are attenuated in their action by naproxen.

Naproxen can reduce the effects of ACE inhibitors while increasing the risk of kidney damage.

Probenecid and sulfinpyrazone reduce naproxen excretion, increasing the risk of adverse effects.

In addition, the intake of other non-steroidal anti-inflammatory drugs (including the so-called coxibs or selective cyclooxygenase-2 inhibitors) or glucocorticoids increases the risk of side effects, in particular the risk of gastrointestinal bleeding and ulcers is increased.

There is an increased risk of bleeding when using naproxen and oral anticoagulants at the same time.

The kidney damaging effect of ciclosporin is enhanced by naproxen.

In combination with acetylsalicylic acid, the effect of naproxen can be diminished, while the effect of phenobarbital decreases.

Potential Naproxen side effects may include: