Moxifloxacin side effects

What side effects can Moxifloxacin have?

Below you will find the most important information about possible known side effects of Moxifloxacin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Ingestion
Common side effects:
Abdominal pain, headache, dizziness, nausea and vomiting, diarrhea, increased gastric acid production, cardiac arrhythmia (QT prolongation only in the case of potassium deficiency in the blood), taste disorders, increased liver value in the blood. !! !!

Uncommon side effects:
weakness, muscle pain, joint pain, leg pain, back pain, chest pain, malaise, insomnia, dizziness, nervousness, tremors, tingling (in hands and feet), anxiety, confusion, depression, dry mouth, constipation, mouth inflammation , Pharyngitis, tongue inflammation, nausea and vomiting, refusal to eat, fungal infections in the mouth, vaginal yeast infections, vaginal inflammation, flatulence, palpitations, conjunctival fluid retention, increased blood pressure, palpitations, cardiac arrhythmia (also QT prolongation), heart attack, shortness of breath, itching, redness, rash, sweating , Hives, vision problems, blood count changes, anemia, increase in white blood cell count, decrease in granulocytes, reduction or increase in platelet count, changes in blood clotting, increase in pancreatic levels.

Rare side effects:
delusions, depersonalization, disorders of movement, restlessness, sleep disorders, nightmares, convulsions, low blood pressure, fainting (sudden and short-term), tendinitis, dry skin, photosensitivity (nodular rash on exposed skin), tinnitus, Hearing loss (temporary), loss of taste, malodors, drowsiness, confusion, increase in blood sugar, increase in blood lipids, jaundice, renal dysfunction, nephritis (interstitial nephritis).

Very rare side effects and isolated cases:
Stevens-Johnson syndrome (blistered rash with high fever), tendon rupture, cardiac arrhythmia, cardiac arrest, pseudomembranous colitis (severe intestinal inflammation), liver inflammation, psychosis, allergic reaction (facial swelling, Drop in blood pressure, skin rash, circulatory failure), myasthenia gravis aggravation.

Use for injection or infusion – Common side effects:
increase in liver value gamma-GT.

Uncommon side effects:
rapid heartbeat from the ventricles, hypertension, fluid retention in the tissues (edema), colon inflammation (antibiotic-related, in very rare cases with life-threatening complications), brain cramps, delusions, renal dysfunction, kidney failure.

Very rare possible side effects:
Sodium excess in the blood, excess calcium in the blood, anemia (hemolytic anemia), muscle rash (rhabdomyolysis), photosensitivity of the skin.

Special features:
The rarely occurring kidney inflammation seems to occur especially with high dosage of the active ingredient and and longer therapy duration. Signs of such kidney inflammation can be high-foaming urine.

At the first signs of severe skin reaction or inflammation of the liver (fever, weakness, increased bleeding tendency, jaundice) stop treatment and consult your doctor.

What interactions does moxifloxacin show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

When used in combination with class I antiarrhythmic drugs (such as quinidine, disopyramide) and class III (such as amiodarone, sotalol), antidepressants (tri- and tetracyclic antidepressants) and antiallergic agents (H1 antihistamines such as terfenadine, astemizole , Mizolastin) may prolong the heartbeat interval with the risk of cardiac arrhythmias. This risk also exists with concomitant administration of antibiotics (such as sparfloxacin and erythromycin), antimalarials and neuroleptics (such as haloperidol and sertindole) and, inter alia, the gastric agent cisapride. a combination with Moxifloxacin is therefore prohibited.

When moxifloxacin is co-administered with mineral acid-binding agents (antacids), iron supplements, zinc supplements, buffered didanosine preparations (for HIV therapy) or multivitamin preparations, its absorption into the body is inhibited. At least six hours should pass between applications.

Administering glibenclamide (for high blood sugar) with moxifloxacin may result in decreased levels of glibenclamide in the blood. These patients require regular blood glucose monitoring.

The effects of anticoagulants such as warfarin may be enhanced during moxifloxacin therapy. There may be increased bleeding and bleeding time.

Furthermore, the concentration of digoxin (cardiac muscle strengthening effect) in the blood is increased when taken with moxifloxacin. The dose should be adjusted individually by the attending physician.

Potential Moxifloxacin side effects may include:

Effect
Percentage

40%

20%

20%