Modafinil contraindications and warnings


The following provides information on contraindications to the use of Modafinil in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).

When should Modafinil not be used?

Modafinil must not be used in cases of hypersensitivity to the active substance, concomitant treatment with the antihypertensive drug prazosin (no longer on the market in Germany) and a history of dependence on alcohol, medications or drugs. Even with uncontrollable high blood pressure or cardiac arrhythmias, the active ingredient must not be used.

Only with particular care may the doctor use Modafinil in patients with the following comorbidities:

  • severe anxiety (except for treatment in specialized settings)
  • Psychoses, depression or mania in the history, given the possible emergence or worsening of mental discomfort
  • severe liver disease and severe kidney disease. Here, the daily dose must be halved.

Special features:
In patients with respiratory failure during sleep (obstructive sleep apnea / hypopnea syndrome), the physician should monitor the underlying condition and associated cardiovascular disease.

Therapy with This ingredient is not a substitute for sleep, and it is important to try to create a favorable condition for falling asleep during treatment.

What should you watch out for during pregnancy and lactation?

As there is no experience with the use of modafinil in pregnancy, the active substance should not be used during pregnancy. During treatment with modafinil, no mini-pills (containing only progestins) or micropills (particularly low-dose estrogen-progestagen combinations for contraception) should be used, but only normal-dose “birth control pills” or other methods of contraception. This also applies to at least one further monthly cycle after the termination of the drug therapy.

Modafinil should not be used during lactation.

What should be considered in children?

Due to the lack of safety and efficacy studies, modafinil is not approved for use in children and adolescents.

Warnings and Precautions

  • The use of the drug can lead to positive results in doping controls
  • The need for treatment with the drug should be checked by the doctor at regular intervals of one year.
  • The medicine should be discontinued at the first sign of a rash and treatment should not be resumed.
  • Treatment with the drug should only be done after careful diagnosis and by a specialist.
  • Daytime sleepiness as well as the side effects of the medication, such as blurred vision or drowsiness, may affect your ability to drive.

Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.