What side effects can Modafinil have?
Below you will find the most important information about possible known side effects of Modafinil.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).
Very common side effects:
Common side effects:
Liver function test abnormalities, elevation of alkaline phosphatase (dose-dependent), gamma-GT elevation (dose-dependent), tachycardia, palpitations, drowsiness, drowsiness, abnormal sensations, blurred vision, abdominal pain, nausea, dry mouth, diarrhea , Indigestion, constipation, loss of appetite, vascular dilation, weakness, chest pain, nervousness, insomnia, anxiety, depression, thought disorder, confusion.
Occasional side effects:
ECG changes, weight changes, cardiac arrhythmias (extra heartbeats (extrasystoles), heartbeat deceleration), changes in blood count (eosinophil excess, white blood cell deficiency), movement disorders (dyskinesia), muscle tension increase, memory gaps (amnesia), Migraine, fidginess (hyperkinesia), tremor, dizziness, brain irritation, gait disturbances, speech disorders, unpleasant taste, blurred vision, conjunctivitis (dry eye), respiratory distress, cough irritation, asthma, nosebleeds, bloating, heartburn, vomiting, tongue inflammation, dysphagia, mouth sores, urinary changes, Changes in the frequency of urination, sweating, rashes, acne, itching, back pain, neck pain, muscle weakness, muscle pain, muscle twitching, joint pain, leg cramps, appetite increase, diabetes mellitus, lipid metabolism disorders (hypercholesterolemia ), Excess blood sugar, pharyngitis, runny nose and sinusitis, increased blood pressure, hypotension, thirst, water retention in arms and legs, nervous irritability, mild allergic reactions (hay fever), regular disturbances, mood swings, sleep disorder, altered dreams, agitation, libido decrease, hostility , Personality Disorder, Aggression.
Undesirable effects: severe skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis and to shock), blood vessel swelling, hives, hypersensitivity reactions (characterized by symptoms such as fever, rash, swollen lymph nodes and signs concomitant Organ involvement), psychosis, mania, delusions, suicidal thoughts.
In patients with severe impairment of liver or kidney function, the daily dose should be halved by the doctor.
At the first signs of rash, treatment with the drug must be discontinued and must not be restarted.
Patients must also be monitored by their relatives during treatment as it can lead to depression, suicidal thoughts and psychosis.
The active ingredient may promote hypertension and cardiac arrhythmia, especially in patients with sleep disorders (sleep apnea).
The occurrence of skin and hypersensitivity reactions as well as nervous-emotional reactions seems to be closely related to the dosage of modafinil used. Accordingly, the doctor will always start treatment with the lowest recommended dose (200 milligrams) and only increase it in patients with inadequate response to up to 400 milligrams.
What interactions does Modafinil show?
Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).
There is limited experience on the interactions of modafinil with other agents. The active ingredient modafinil accelerates the breakdown of other substances in the liver. Therefore, concomitant use of estrogen-progestagen combinations for contraception, clomipramine and desipramine (tricyclic antidepressants), epilepsy agents such as phenytoin, from cyclosporine (for organ transplantation rejection reactions), the asthma drug theophylline, the blood thinner warfarin, the benzodiazepine diazepam and the beta-blocker propranolol are expected to reduce the effect.
However, in clinical studies where clomipramine or methylphenidate (a phenytoin relative) were both given concurrently with modafinil in low doses, there was no interaction.
If estrogen-progestagen combinations are used for contraception, their contraceptive effect may be reduced during treatment with modafinil and for one cycle after the end of treatment. This is especially true for mini and micro pill, which contain either only progestins or particularly little hormones. During treatment with modafinil, it is therefore essential to use normal-dose contraceptive pills (ethinylestradiol content at least 0.05 milligrams) or other contraceptive methods.