The following provides information on contraindications to the use of desmopressin in general, pregnancy & amp; Breastfeeding and children. Please note that the contraindications may vary depending on the dosage form of a drug (eg tablet, syringe, ointment).
When may desmopressin not be used?
Desmopressin must not be given at
- Hypersensitivity to the active substance
- Patients suffering from increased thirst and increased fluid intake due to mental health should not use desmopressin. The same applies to alcoholics with recurring diseased thirst and pathologically increased fluid intake
- Blood coagulation disorders such as the severe classic von Willebrand-Jürgens syndrome (type IIb), patients with 5% factor VIII activity or antibodies to coagulation factor VIII
- Heart failure and other conditions requiring treatment with dehydrators.
- blood sodium deficiency
- mild or severe renal impairment (creatinine clearance less than 50 milliliters / minute)
- Increased secretion of antidiuretic hormone (ADH).
A medical benefit-risk assessment is essential in
- the treatment of young and elderly patients
- Disorders of fluid and / or mineral balance
- Risk of increased pressure in the brain
- the connective tissue disease cystic fibrosis
- Tendency to block blood vessels
- impaired kidney function.
The treatment of nocturnal bedwetting with desmopressin should only be used in patients with normal blood pressure. It should be noted that the use of nasal sprays for this application can lead to severe blood sodium depletion.
Renal excretion slows down the excretion of the drug, so lower doses are required.
When using desmopressin as a nasal spray, changes or diseases of the nasal mucosa may lead to an altered intake of desmopressin. In these cases, desmopressin should not be used as a dosing spray.
In general, fluid intake should be limited during treatment with desmopressin.
What should you watch out for during pregnancy and lactation?
Regarding the use of desmopressin in pregnancy and lactation via the nose, the previous studies show no evidence of adverse effects for mother and child. When prescribing Desmopressin in tablet form for pregnant women, medical attention is advised. The blood pressure must be constantly monitored in such cases. The use of desmopressin for the lack of antidiuretic hormone (ADH) in pregnancy in the form of injections is safe if a permanent medical check-up takes place.
The use of the active substance during breast-feeding is safe for the child.
What should be considered in children?
In most cases, desmopressin can be used as early as infancy if it allows the dosage form (syringe, spray).
Warnings and Precautions
- Fluid intake should be kept to a minimum during treatment with the drug.
- During treatment with the drug, the physician must prevent a possible blood sodium deficiency.
Sometimes medications release allergic reactions.
If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.