Minirin side effects

What side effects can desmopressin have?

Below you will find the most important information about possible, known side effects of Desmopressin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Spray
Common Side Effects:
Nasal congestion, nosebleeds, runny nose, nausea and vomiting, abdominal pain, headache.

Rare side effects:
brain swelling, sodium deficiency cramps.

Very rare side effects:
allergic reactions, hypersensitivity reactions (itching, rash, fever, bronchospasm, shock), blood sodium deficiency.

Syringe
Common Side Effects:
Nausea and vomiting, abdominal pain, headache.

Rare side effects:
brain swelling, sodium deficiency cramps.

Very rare side effects:
allergic reactions, hypersensitivity reactions (itching, rash, fever, bronchospasm, shock), blood sodium deficiency.

Tablets
Common Side Effects:
Nausea, Abdominal Pain, Headache.

Rare side effects:
brain swelling, sodium deficiency cramps.

Very rare side effects:
allergic skin reactions, general allergic reactions, blood sodium deficiency, mental disorders (mainly in children).

Special features:
Excessive hydration and the use of very high dosages can cause weight gain and convulsions, especially in very young and elderly patients.

What interactions does desmopressin show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Substances that increase the release of anti-diuretic hormone (ADH) such as antidepressants (selective serotonin reuptake inhibitors and chlorpromazine), the epilepsy agent carbamazepine and non-steroidal anti-inflammatory drugs (eg indomethacin) may increase the effect of desmopressin. This increases the risk of water retention in the body and sodium deficiency in the blood.

The water-retaining effect of desmopressin can be further enhanced by the blood lipid lowering agent clofibrate and the labor-promoting hormone oxytocin.

Concomitant treatment with the diarrhea stopper loperamide may result in a threefold increase in blood desmopressin levels. This also leads to an increased water storage and an increased risk of blood sodium deficiency.

The oral antidiabetic agent glibenclamide and the antidepressant lithium may attenuate the effects of desmopressin.

A diet containing almost one-third fat reduces significantly the absorption of the drug into the body. Although this is only for a very low dose of Desmopressin tablets, the tablets should be taken with a meal-time interval.

Potential Minirin side effects may include:

Effect
Percentage