Metformin side effects

What side effects does metformin have?

Below you will find the most important information about possible known side effects of metformin.
These side effects do not occur, but you can. Because every person reacts differently to medication. Please also note that the type and frequency of side effects may vary depending on the drug formulation (eg tablet, syringe, ointment).

Very common side effects:
nausea and vomiting, diarrhea, abdominal pain, loss of appetite.

Common side effects:
taste change

Very rare side effects:
redness, itching, hives, vitamin B12 deficiency (in long-term use), metabolic derangement (lactic acidosis), liver-enzyme abnormality, hepatitis.

Special features:
Especially at the beginning of therapy gastrointestinal complaints may occur, but in most cases they will disappear on their own. To prevent these symptoms, metformin is recommended during or after meals in the form of two or three take three single doses. A slow increase in dosage can also promote tolerability.

Long-term use of metformin sometimes results in decreased intake of vitamin B12 and, consequently, deficiency of the vitamin in the blood. This must be considered by the doctor as a possible cause of anemia (megaloblastic anemia).

What interactions does metformin show?

Please note that the interactions may vary depending on the drug formulation of a drug (eg tablet, syringe, ointment).

Glucocorticoids (“cortisone”), dehydrators and asthma drugs from the drug group of beta-2-sympathomimetics can reduce the blood sugar-lowering effect of the drug.

Cardiovascular drugs from the group of ACE inhibitors can lead to a Increased lowering of blood sugar levels and low blood sugar levels.

There is an increased risk of lactic acidosis

  • with alcohol consumption or even alcohol poisoning, especially in connection with fasting
  • when injecting iodine-containing X-ray contrast media into the blood vessels. It can also cause kidney failure.

Potential Metformin side effects may include: